Selective localization of γ-enolase in stromal cells of cerebellar hemangioblastomas
dc.contributor.author | McKeever, Paul E. | en_US |
dc.contributor.author | Feldenzer, John A. | en_US |
dc.date.accessioned | 2006-09-11T18:44:11Z | |
dc.date.available | 2006-09-11T18:44:11Z | |
dc.date.issued | 1987-09 | en_US |
dc.identifier.citation | Feldenzer, J. A.; McKeever, P. E.; (1987). "Selective localization of γ-enolase in stromal cells of cerebellar hemangioblastomas." Acta Neuropathologica 72(3): 281-285. <http://hdl.handle.net/2027.42/47228> | en_US |
dc.identifier.issn | 0001-6322 | en_US |
dc.identifier.issn | 1432-0533 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47228 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3105228&dopt=citation | en_US |
dc.description.abstract | Three cases of cerebellar hemangioblastoma were studied using the immunoperoxidase technique to localize γ-enolase, also known as neuron-specific enolase. The stromal cells demonstrated positive staining for γ-enolase, while endothelial cells and pericytes showed no reactivity. Two vascular lesions, an angiosarcoma and a cutaneous angioma, were studied and found to be nonreactive for γ-enolase. All tumors were also tested for factor VIII/von Willebrand factor, glial fibrillary acidic protein, and the S-100 protein. The lack of expression of γ-enolase in endothelial cells of hemangioblastomas demonstrates a clear antigenic distinction from neighboring γ-enolase-positive stromal cells. The significance of this finding and its implications for stromal cell histogenesis are discussed. | en_US |
dc.format.extent | 978964 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag GmbH & Co. KG | en_US |
dc.subject.other | Neuron-specific Enolase | en_US |
dc.subject.other | Immunohistochemistry | en_US |
dc.subject.other | Stromal Cell | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | γ-Enolase | en_US |
dc.subject.other | Cerebellar Hemangioblastoma | en_US |
dc.subject.other | Pathology | en_US |
dc.title | Selective localization of γ-enolase in stromal cells of cerebellar hemangioblastomas | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, Section of Neurosurgery, Taubman Health Care Center, University of Michigan, 1500 E. Medical Center Drive, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, Section of Neuropathology, Taubman Health Care Center, University of Michigan, 1500 E. Medical Center Drive, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3105228 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47228/1/401_2004_Article_BF00691102.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00691102 | en_US |
dc.identifier.source | Acta Neuropathologica | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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