Increased aggregation and arachidonic acid transformation by psoriatic platelets: evidence that platelet-derived 12-hydroxy-eicosatetraenoic acid increases keratinocyte DNA synthesis in vitro
dc.contributor.author | Fallon, J. D. | en_US |
dc.contributor.author | Kragballe, K. | en_US |
dc.date.accessioned | 2006-09-11T18:44:47Z | |
dc.date.available | 2006-09-11T18:44:47Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Kragballe, K.; Fallon, J. D.; (1986). "Increased aggregation and arachidonic acid transformation by psoriatic platelets: evidence that platelet-derived 12-hydroxy-eicosatetraenoic acid increases keratinocyte DNA synthesis in vitro." Archives of Dermatological Research 278(6): 449-453. <http://hdl.handle.net/2027.42/47237> | en_US |
dc.identifier.issn | 0340-3696 | en_US |
dc.identifier.issn | 1432-069X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47237 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2431657&dopt=citation | en_US |
dc.description.abstract | Certain archidonic metabolites may play a pathogenic role in psoriasis. Platelets are rich sources of 12-hydroxy-eicosatetraenoic acid (12-HETE) and thromboxane A 2 , mediators of skin inflammation and platelet aggregation, respectively. We have studied untreated psoriatic patients without a history of diabetes mellitus and smoking. In psoriatics, platelet aggregation elicited by thrombin, ADP, and ristocetin was significantly enhanced as compared with healthy adult volunteers. Enhancement of platelet aggregation was detected in patients with both minimal and widespread disease. The formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), a cyclooxygenase product, and 12-HETE, a 12-lipoxygenase product, was increased in psoriatics with widespread disease but not in those with minimal disease. Formation of 12-HETE was stimulated to a higher degree (125%) than HHT (98%) in psoriasis ( P <0.05). Addition of platelet-derived 12-HETE to cultured human epidermal keratinocytes resulted in a stimulation of the DNA synthesis (68% at 10 -7 M ). These data suggest that platelet activation occurs in psoriasis, and that release of inflammatory and mitogenic compounds by activated platelets may play a role in the pathophysiology of psoriasis. Whether enhanced platelet aggregation in psoriasis is associated with occlusive vascular disease needs further investigation. | en_US |
dc.format.extent | 476047 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag GmbH & Co. KG | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Psoriasis | en_US |
dc.subject.other | Platelet Aggregation | en_US |
dc.subject.other | Arachidonate Metabolites | en_US |
dc.subject.other | Dermatology | en_US |
dc.subject.other | DNA Synthesis | en_US |
dc.title | Increased aggregation and arachidonic acid transformation by psoriatic platelets: evidence that platelet-derived 12-hydroxy-eicosatetraenoic acid increases keratinocyte DNA synthesis in vitro | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dermatology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Dermatologisk afdeling, Marselisborg Hospital, DK-8000, Aarhus C, Denmark | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2431657 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47237/1/403_2004_Article_BF00455162.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00455162 | en_US |
dc.identifier.source | Archives of Dermatological Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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