Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney
dc.contributor.author | Schacht, Jochen | en_US |
dc.date.accessioned | 2006-09-11T18:46:23Z | |
dc.date.available | 2006-09-11T18:46:23Z | |
dc.date.issued | 1979-03 | en_US |
dc.identifier.citation | Schacht, Jochen; (1979). "Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney." Archives of Oto-Rhino-Laryngology 224 (1-2): 129-134. <http://hdl.handle.net/2027.42/47260> | en_US |
dc.identifier.issn | 0302-9530 | en_US |
dc.identifier.issn | 1434-4726 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47260 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=226045&dopt=citation | en_US |
dc.description.abstract | Affinity chromatography was used to isolate aminoglycoside receptors from inner ear tissues and kidney. Neomycin was immobilized on glass beads and served as the stationary phase in column chromatography. Fractionation of an organic tissue extract on this matrix demonstrated two components with high affinity for neomycin: phosphatidyl inositol phosphate and phosphatidyl inositol diphosphate. The toxicity of aminoglycosides is explained on the basis of a drug-interaction with these lipids. | en_US |
dc.format.extent | 608986 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Neurosurgery | en_US |
dc.subject.other | Affinity Chromatography | en_US |
dc.subject.other | Polyphosphoinositides | en_US |
dc.subject.other | Drug Receptors | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Aminoglycoside Ototoxicity | en_US |
dc.subject.other | Otorhinolaryngology | en_US |
dc.subject.other | Neomycin | en_US |
dc.title | Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 226045 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47260/1/405_2004_Article_BF00455236.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00455236 | en_US |
dc.identifier.source | Archives of Oto-Rhino-Laryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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