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Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney

dc.contributor.authorSchacht, Jochenen_US
dc.date.accessioned2006-09-11T18:46:23Z
dc.date.available2006-09-11T18:46:23Z
dc.date.issued1979-03en_US
dc.identifier.citationSchacht, Jochen; (1979). "Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney." Archives of Oto-Rhino-Laryngology 224 (1-2): 129-134. <http://hdl.handle.net/2027.42/47260>en_US
dc.identifier.issn0302-9530en_US
dc.identifier.issn1434-4726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47260
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=226045&dopt=citationen_US
dc.description.abstractAffinity chromatography was used to isolate aminoglycoside receptors from inner ear tissues and kidney. Neomycin was immobilized on glass beads and served as the stationary phase in column chromatography. Fractionation of an organic tissue extract on this matrix demonstrated two components with high affinity for neomycin: phosphatidyl inositol phosphate and phosphatidyl inositol diphosphate. The toxicity of aminoglycosides is explained on the basis of a drug-interaction with these lipids.en_US
dc.format.extent608986 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherNeurosurgeryen_US
dc.subject.otherAffinity Chromatographyen_US
dc.subject.otherPolyphosphoinositidesen_US
dc.subject.otherDrug Receptorsen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherAminoglycoside Ototoxicityen_US
dc.subject.otherOtorhinolaryngologyen_US
dc.subject.otherNeomycinen_US
dc.titleIsolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidneyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid226045en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47260/1/405_2004_Article_BF00455236.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00455236en_US
dc.identifier.sourceArchives of Oto-Rhino-Laryngologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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