Are aminosugars ototoxic?
dc.contributor.author | Schindler, K. | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.contributor.author | Jung, W. | en_US |
dc.contributor.author | Tachibana, M. | en_US |
dc.date.accessioned | 2006-09-11T18:46:39Z | |
dc.date.available | 2006-09-11T18:46:39Z | |
dc.date.issued | 1981-04 | en_US |
dc.identifier.citation | Tachibana, M.; Jung, W.; Schindler, K.; Schacht, J.; (1981). "Are aminosugars ototoxic?." Archives of Oto-Rhino-Laryngology 230(2): 103-107. <http://hdl.handle.net/2027.42/47264> | en_US |
dc.identifier.issn | 1434-4726 | en_US |
dc.identifier.issn | 0302-9530 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47264 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7295169&dopt=citation | en_US |
dc.description.abstract | Die Ototoxizität des Kanamycin-Fragmentes 3-Amino-3-deoxy- D -glukose (3-Aminoglukose, Kanosamin) wurde via perilymphatischer Perfusion am Meerschweinchen untersucht. Im Gegensatz zu früheren Befunden (Owada 1962) konnte bei Konzentrationen von 10 oder 28 mM kein Einfluß auf das Mikrophonpotential (CM) festgestellt werden. Kanamycin erniedrigte CM signifikant bereits bei 1 mM, und dieser Effekt war wenigstens teilweise reversibel. The ototoxicity of the kanamycin fragment 3-amino-3-deoxy- D -glucose (3-aminoglucose, kanosamine), was investigated by perilymphatic perfusion in the guinea pig. Concentrations of 10 or 28 mM of this compound had no effect on cochlear microphonic potentials (CM), contrasting with previous observations (Owada 1962). Kanamycin at 1 mM decreased CM significantly under otherwise identical conditions. The action of kanamycin was at least partially reversible. | en_US |
dc.format.extent | 252893 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Aminoglykosid-Antibiotika | en_US |
dc.subject.other | Aminosugars | en_US |
dc.subject.other | Mikrophonpotentiale | en_US |
dc.subject.other | Otorhinolaryngology | en_US |
dc.subject.other | OtotoxizitäT | en_US |
dc.subject.other | Ototoxicity | en_US |
dc.subject.other | Perilymphatische Perfusion | en_US |
dc.subject.other | Aminozucker | en_US |
dc.subject.other | Aminoglycosides | en_US |
dc.subject.other | Cochlear Microphonic | en_US |
dc.subject.other | Perilymphatic Perfusion | en_US |
dc.subject.other | Neurosurgery | en_US |
dc.title | Are aminosugars ototoxic? | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 48109, Ann Arbor, MI, USA; Department of Otolaryngology, Kyoto Prefectural University of Medicine, Kamikyo-Ku, 602, Kyoto, Japan | en_US |
dc.contributor.affiliationother | Division of Experimental Otorhinolaryngology, Dept. of Otorhinolaryngology, University of Würzburg, D-8700, Würzburg, Germany | en_US |
dc.contributor.affiliationother | Division of Experimental Otorhinolaryngology, Dept. of Otorhinolaryngology, University of Würzburg, D-8700, Würzburg, Germany | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7295169 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47264/1/405_2004_Article_BF00456138.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00456138 | en_US |
dc.identifier.source | Archives of Oto-Rhino-Laryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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