Detection of cancer recurrence in irradiated mandible using positron emission tomography
dc.contributor.author | Minn, H. | en_US |
dc.contributor.author | Aitasalo, K. | en_US |
dc.contributor.author | Happonen, R. -P. | en_US |
dc.date.accessioned | 2006-09-11T18:47:28Z | |
dc.date.available | 2006-09-11T18:47:28Z | |
dc.date.issued | 1993-09 | en_US |
dc.identifier.citation | Minn, H.; Aitasalo, K.; Happonen, R.-P.; (1993). "Detection of cancer recurrence in irradiated mandible using positron emission tomography." European Archives of Oto-Rhino-Laryngology 250(5): 312-315. <http://hdl.handle.net/2027.42/47276> | en_US |
dc.identifier.issn | 0937-4477 | en_US |
dc.identifier.issn | 1434-4726 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47276 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8217137&dopt=citation | en_US |
dc.description.abstract | Positron emission tomography (PET) is a promising method for pretherapeutic assessment of spread of squamous cell carcinomas (SCC) in the head and neck. A 41-year-old man with a history of operated and irradiated SCC of the tongue presented 4 years later with symptoms and signs of mandibular osteoradionecrosis. No changes related to malignancy could be seen in panoramic radiographs or computed tomography scanning with contrast enhancement. Since a biopsy of the involved region was positive for SCC, a PET study with [ 18 F]fluorodeoxyglucose (FDG) was performed. In dynamic PET images, intensive uptake of FDG was seen in a small area close to the right mental foramen. A hemimandibulectomy with reconstruction using a free vascularized graft from iliac crest was performed. In the resected specimen, histological examination showed a 1.2-mm focus of SCC in the soft tissue and bone around the mental foramen. These findings indicate that FDG-PET might be useful for presurgical evaluation of cancer recurrence in a previously irradiated mandible, especially if PET can accurately differentiate viable tumor tissue from radiation-induced fibrosis and inflammation. | en_US |
dc.format.extent | 416073 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Osteoradionecrosis | en_US |
dc.subject.other | Squamous Cell Carcinoma | en_US |
dc.subject.other | Radionuclide Imaging | en_US |
dc.subject.other | Emission Computed Tomography | en_US |
dc.subject.other | Neurosurgery | en_US |
dc.subject.other | Otorhinolaryngology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | Detection of cancer recurrence in irradiated mandible using positron emission tomography | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oncology, University of Turku, SF-20520, Turku, Finland; Turku University Cyclotron/PET Center, University of Turku, SF-20520, Turku, Finland; Department of Internal Medicine, Divison of Nuclear Medicine, University of Michigan Medical Center, University Hospital B1G412, 48109-0028, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Institute of Dentistry, University of Turku, SF-20520, Turku, Finland | en_US |
dc.contributor.affiliationother | Department of Radiotherapy, University of Turku, SF-20520, Turku, Finland | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8217137 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47276/1/405_2004_Article_BF00186234.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00186234 | en_US |
dc.identifier.source | European Archives of Oto-Rhino-Laryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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