Effects of Ginkgo biloba extract (EGb 761) on cochlear vasculature in the guinea pig: morphometric measurements and laser Doppler flowmetry
dc.contributor.author | Aurousseau, C. | en_US |
dc.contributor.author | Didier, Anne | en_US |
dc.contributor.author | Cazals, Yves | en_US |
dc.contributor.author | Droy-Lefaix, M. -T. | en_US |
dc.date.accessioned | 2006-09-11T18:47:40Z | |
dc.date.available | 2006-09-11T18:47:40Z | |
dc.date.issued | 1996-01 | en_US |
dc.identifier.citation | Didier, A.; Droy-Lefaix, M. -T.; Aurousseau, C.; Cazals, Y.; (1996). "Effects of Ginkgo biloba extract (EGb 761) on cochlear vasculature in the guinea pig: morphometric measurements and laser Doppler flowmetry." European Archives of Oto-Rhino-Laryngology 253 (1-2): 25-30. <http://hdl.handle.net/2027.42/47279> | en_US |
dc.identifier.issn | 1434-4726 | en_US |
dc.identifier.issn | 0937-4477 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47279 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8932425&dopt=citation | en_US |
dc.description.abstract | Ginkgo biloba extract (EGb 761) was administered orally for 4 or 6 weeks to healthy adult guinea pigs. Animals were then decapitated under deep ketamine anesthesia. Post-mortem morphometric measurements of cochlear vessels in the spiral lamina revealed a vasodilating effect of the extract in four of ten animals following 6 weeks of treatment. In vivo testing of the effect of 4 or 6 weeks of treatment with EGb 761 was monitored with laser Doppler flowmetry of the cochlear blood flow under pathological conditions. Results demonstrated that EGb 761 partly counteracted sodium salicylate-induced decreases in cochlear blood flow (CBF) and enhanced CBF increases induced by hypoxia. These findings indicate that EGb 761 may help to improve oxygenation in cochleas with compromised blood flow. | en_US |
dc.format.extent | 576454 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Ginkgo Biloba Extract | en_US |
dc.subject.other | Cochlear Blood Flow | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Otorhinolaryngology | en_US |
dc.subject.other | Neurosurgery | en_US |
dc.subject.other | Hypoxia | en_US |
dc.subject.other | Ototoxicity Laser Doppler Flowmetry | en_US |
dc.title | Effects of Ginkgo biloba extract (EGb 761) on cochlear vasculature in the guinea pig: morphometric measurements and laser Doppler flowmetry | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, 48109-0506, Ann Arbor, MI, USA; Laboratoire de Physiologie Neurosensorielle, University Claude Bernard, 43 bld du 11 Novembre 1918, F-69622, Villeurbanne, France | en_US |
dc.contributor.affiliationother | Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France | en_US |
dc.contributor.affiliationother | Ipsen Institute, F-75781, 16, Paris cedex, France | en_US |
dc.contributor.affiliationother | Laboratoire d'Audiologie Expérimentale, Inserm U 229, Hôpital Pellegrin, F-33076, Bordeaux, France | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8932425 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47279/1/405_2004_Article_BF00176698.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00176698 | en_US |
dc.identifier.source | European Archives of Oto-Rhino-Laryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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