S100 is preferentially distributed in myelin-forming Schwann cells

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dc.contributor.author Mata, Marina en_US
dc.contributor.author Alessi, Diane M. en_US
dc.contributor.author Fink, David J. en_US
dc.date.accessioned 2006-09-11T18:56:58Z
dc.date.available 2006-09-11T18:56:58Z
dc.date.issued 1990-06 en_US
dc.identifier.citation Mata, M.; Alessi, D.; Fink, D. J.; (1990). "S100 is preferentially distributed in myelin-forming Schwann cells." Journal of Neurocytology 19(3): 432-442. <http://hdl.handle.net/2027.42/47412> en_US
dc.identifier.issn 0300-4864 en_US
dc.identifier.issn 1573-7381 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/47412
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2391542&dopt=citation en_US
dc.description.abstract In order to elucidate the role of S100 protein in vivo we used postembedding electron microscopical immunocytochemistry with commercially available antibodies to S100, and secondary antibodies conjugated to colloidal gold to determine the distribution of S100 protein in the sciatic nerve and the cervical sympathetic trunk of the rat. We found that S100 immunoreactivity in Schwann cells was differentially distributed. The amount of S100 immunoreactivity in myelinated fibres appeared to correlate directly with the thickness of the myelin sheath formed by the Schwann cell. Unmyelinated fibres were identical to the small myelinated fibres in S100 immunoreactivity. Within the Schwann cells, the immunoreactivity was seen in the nucleus and in the perikaryal cytoplasm, as well as in the Schmidt-Lanterman clefts and in the paranodal loops at the node of Ranvier, but not in the myelin itself. Using these antibodies we did not see reproducible or convincing intra-axonal immunoreactivity in normal nerve. en_US
dc.format.extent 6866858 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Kluwer Academic Publishers; Chapman and Hall Ltd ; Springer Science+Business Media en_US
dc.subject.other Biomedicine en_US
dc.subject.other Neurosciences en_US
dc.subject.other Neuroradiology en_US
dc.title S100 is preferentially distributed in myelin-forming Schwann cells en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology (127), 2215 Fuller Road, 48105, Ann Arbor, MI, USA en_US
dc.contributor.affiliationum Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA en_US
dc.contributor.affiliationum Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 2391542 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/47412/1/11068_2005_Article_BF01188409.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF01188409 en_US
dc.identifier.source Journal of Neurocytology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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