Differential respirable dust related lung function effects between current and former South African coal miners
dc.contributor.author | Becklake, Margaret | en_US |
dc.contributor.author | Lalloo, Umesh G. | en_US |
dc.contributor.author | Naidoo, Rajen N. | en_US |
dc.contributor.author | Seixas, Noah | en_US |
dc.contributor.author | Robins, Thomas G. | en_US |
dc.date.accessioned | 2006-09-11T18:57:10Z | |
dc.date.available | 2006-09-11T18:57:10Z | |
dc.date.issued | 2005-05 | en_US |
dc.identifier.citation | Naidoo, Rajen N.; Robins, Thomas G.; Seixas, Noah; Lalloo, Umesh G.; Becklake, Margaret; (2005). "Differential respirable dust related lung function effects between current and former South African coal miners." International Archives of Occupational and Environmental Health 78(4): 293-302. <http://hdl.handle.net/2027.42/47415> | en_US |
dc.identifier.issn | 0340-0131 | en_US |
dc.identifier.issn | 1432-1246 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47415 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15785947&dopt=citation | en_US |
dc.description.abstract | Dust-related dose-response decrements in lung function among coal miners have been reported in several studies, with varying magnitudes across populations. Few studies have compared differences between current and former coal miners. No studies on dose response relationships with lung function have been conducted in South African coal mines, one of the top three producers of coal internationally. The objectives of this study were (1) to describe the relationship between respirable dust exposure and lung function among current and former South African coal miners and to determine whether differential dust related effects were present between these employment categories; (2) to examine dust related dose response relationships, controlling for potential confounding by smoking and a history of tuberculosis (TB). Six hundred and eighty-four current and 188 ex-miners from three bituminous coal mines in Mpumalanga Province were studied. Interviews assessing work histories, smoking profiles and other risk factors were conducted. Work histories were also obtained from company records. Standardised spirometry was performed by trained technicians. Cumulative respirable dust exposure (CDE) estimates were constructed from company-collected sampling and measurements conducted by the researchers. Regression models examined the associations of CDE with per cent predicted FEV 1 and FVC, controlling for smoking, past history of TB and employment status. A statistically significant decline in FEV 1 of 1.1 and 2.2 ml/mg-year/m 3 was found in representative 40-year-old, 1.7-m tall current and former miners, respectively. Significant differences were found between the highest and medium exposure categories. Ex-miners had a lower mean per cent predicted lung function than current miners for each cumulative exposure category, suggesting a “healthy worker” effect. Past history of TB contributed to 21 and 14% declines in per cent predicted FEV 1 and FVC, respectively. Thus, in this cohort, a dose-related decline in lung function was associated with respirable dust exposure, with a magnitude of effect similar to that seen in other studies and important differences between current and former employees. A “healthy worker” effect may have attenuated the magnitude of this relationship. TB was a significant contributor to lung function loss. | en_US |
dc.format.extent | 291364 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Dose Response Relationship | en_US |
dc.subject.other | Medicine | en_US |
dc.subject.other | Lung Function | en_US |
dc.subject.other | Cumulative Dust Exposure | en_US |
dc.subject.other | Coal Dust | en_US |
dc.title | Differential respirable dust related lung function effects between current and former South African coal miners | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029, USA | en_US |
dc.contributor.affiliationother | McGill University/Respiratory Epidemiology Unit, Montreal Chest Institute, 3650 St-Urbain Street, Montreal, Quebec, H2X 2P4, Canada | en_US |
dc.contributor.affiliationother | Department of Environmental Health, University of Washington, 357234, Seattle, WA 98195-7234, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Private Bag x7, Congella, 4013, South Africa | en_US |
dc.contributor.affiliationother | Centre for Occupational and Environmental Health/Department of Community Health, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Private Bag x7, Congella, 4013, South Africa | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15785947 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47415/1/420_2005_Article_602.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00420-005-0602-1 | en_US |
dc.identifier.source | International Archives of Occupational and Environmental Health | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.