Intrinsic difference in erythrocyte membrane in spontaneously hypertensive rats characterized by Na + and K + fluxes
dc.contributor.author | Ven, Cosmas J. M. | en_US |
dc.contributor.author | Bohr, David F. | en_US |
dc.date.accessioned | 2006-09-11T18:59:33Z | |
dc.date.available | 2006-09-11T18:59:33Z | |
dc.date.issued | 1983-09 | en_US |
dc.identifier.citation | Ven, Cosmas J. M.; Bohr, David F.; (1983). "Intrinsic difference in erythrocyte membrane in spontaneously hypertensive rats characterized by Na + and K + fluxes." Pflügers Archiv European Journal of Physiology 399(1): 74-78. <http://hdl.handle.net/2027.42/47450> | en_US |
dc.identifier.issn | 0031-6768 | en_US |
dc.identifier.issn | 1432-2013 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47450 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6647002&dopt=citation | en_US |
dc.description.abstract | The goad of this study was to determine whether the elevated flux of sodium and potassium through the erythrocyte membrane of spontaneously hypertensive rats (SHR) is due to an intrinsic difference in the cell membrane or to a humoral factor present in the plasma. Isolated and washed erythrocytes from SHR and normotensive Wistar Kyoto (WKy) and Sprague-Dawley (SD) rats, were incubated in 1) a physiological salt solution, 2) WKy or SD plasma and 3) SHR plasma. Incubations were performed at 4°C for 23 h. Erythrocytes from SHR incubated in physiological salt solution had significantly greater Na + and K + fluxes than those from normotensive WKy and SD rats ( P <0.005). Plasma from any of the three strains of rats, as compared to physiological salt solution, increased Na + influx in the following order: SD>WKy>SHR. Erythrocyte K + efflux was not altered by plasma. We conclude that the elevated flux of Na + and K + in SHR erythrocytes is due to an intrinsic difference in the cell membrane. The greater Na + influx in plasma from any strain of rats is not correlated with the blood pressure of the rat. The lesser increase in Na + influx in crythrocytes incubated in plasma from SHR masks the greater intrinsic membrane permeability in the SHR erythrocyte when Na + fluxes are studied in whole blood. The elevated flux of Na + and K + through the erythrocyte membrane of SHR may reflect a general membrane defect that underlies the pathogenesis of elevated arterial pressure. | en_US |
dc.format.extent | 569265 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Human Physiology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Sodium and Potassium Permeability | en_US |
dc.subject.other | Hypertension | en_US |
dc.subject.other | Plasma Factor | en_US |
dc.title | Intrinsic difference in erythrocyte membrane in spontaneously hypertensive rats characterized by Na + and K + fluxes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Medical School, 7710 Med. Sci. II, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Medical School, 7710 Med. Sci. II, 48109, Ann Arbor, Michigan, USA; Medical School, Leiden, University of Leiden, Cosmas van de Ven, Herungerweg 344, NL-5916 ND, Venlo, The Netherlands | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6647002 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47450/1/424_2004_Article_BF00652525.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00652525 | en_US |
dc.identifier.source | Pflügers Archiv European Journal of Physiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.