Hair cells in the inner ear of the pirouette and shaker 2 mutant mice
dc.contributor.author | Beyer, Lisa A. | en_US |
dc.contributor.author | Odeh, Hana | en_US |
dc.contributor.author | Probst, Frank J. | en_US |
dc.contributor.author | Lambert, Erica H. | en_US |
dc.contributor.author | Dolan, David F. | en_US |
dc.contributor.author | Camper, Sally A. | en_US |
dc.contributor.author | Kohrman, David C. | en_US |
dc.contributor.author | Raphael, Yehoash | en_US |
dc.date.accessioned | 2006-09-11T19:00:18Z | |
dc.date.available | 2006-09-11T19:00:18Z | |
dc.date.issued | 2000-04 | en_US |
dc.identifier.citation | Beyer, Lisa A.; Odeh, Hana; Probst, Frank J.; Lambert, Erica H.; Dolan, David F.; Camper, Sally A.; Kohrman, David C.; Raphael, Yehoash; (2000). "Hair cells in the inner ear of the pirouette and shaker 2 mutant mice." Journal of Neurocytology 29(4): 227-240. <http://hdl.handle.net/2027.42/47461> | en_US |
dc.identifier.issn | 0300-4864 | en_US |
dc.identifier.issn | 1573-7381 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47461 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11276175&dopt=citation | en_US |
dc.description.abstract | The shaker 2 ( sh2 ) and pirouette ( pi ) mouse mutants display severe inner ear dysfunction that involves both auditory and vestibular manifestation. Pathology of the stereocilia of hair cells has been found in both mutants. This study was designed to further our knowledge of the pathological characteristics of the inner ear sensory epithelia in both the sh2 and pi strains. Measurements of auditory brainstem responses indicated that both mutants were profoundly deaf. The morphological assays were specifically designed to characterize a pathological actin bundle that is found in both the inner hair cells and the vestibular hair cells in all five vestibular organs in these two mutants. Using light microscope analysis of phalloidin-stained specimens, these actin bundles could first be detected on postnatal day 3. As the cochleae matured, each inner hair cell and type I vestibular hair cell contained a bundle that spans from the region of the cuticular plate to the basal end of the cell, then extends along with cytoplasm and membrane, towards the basement membrane. Abnormal contact with the basement membrane was found in vestibular hair cells. Based on the shape of the cellular extension and the actin bundle that supports it, we propose to name these extensions “cytocauds.” The data suggest that the cytocauds in type I vestibular hair cells and inner hair cells are associated with a failure to differentiate and detach from the basement membrane. | en_US |
dc.format.extent | 3940382 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Neuroradiology | en_US |
dc.title | Hair cells in the inner ear of the pirouette and shaker 2 mutant mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Human Genetics, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Human Genetics, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationum | The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11276175 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47461/1/11068_2004_Article_278960.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1026515619443 | en_US |
dc.identifier.source | Journal of Neurocytology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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