Neonatal deafening causes changes in Fos protein induced by cochlear electrical stimulation
dc.contributor.author | Nagase, Shigeyo | en_US |
dc.contributor.author | Mukaida, Masahiro | en_US |
dc.contributor.author | Miller, Josef M. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2006-09-11T19:00:30Z | |
dc.date.available | 2006-09-11T19:00:30Z | |
dc.date.issued | 2003-05 | en_US |
dc.identifier.citation | Nagase, Shigeyo; Mukaida, Masahiro; Miller, Josef M.; Altschuler, Richard A.; (2003). "Neonatal deafening causes changes in Fos protein induced by cochlear electrical stimulation." Journal of Neurocytology 32(4): 353-361. <http://hdl.handle.net/2027.42/47464> | en_US |
dc.identifier.issn | 0300-4864 | en_US |
dc.identifier.issn | 1573-7381 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47464 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14724378&dopt=citation | en_US |
dc.description.abstract | The influence of neonatal deafness on cochlear electrically evoked Fos expression in the auditory brainstem was examined. Newborn rats were deafened by systemic injection of kanamycin, 1 mg/g daily for 12 days. At 4, 5, 6 or 8 weeks of age, these animals received cochlear electrical stimulation with a basal monopolar electrode for 90 minutes. Age-matched untreated control animals received similar stimulation. Experimental and control animals were assessed for spiral ganglion cell densities and Fos immunoreactive staining in the central nucleus of the inferior colliculus. Spiral ganglion cell assessments showed significant decreases in spiral ganglion cell densities in deafened rats compared to age-matched controls, at 5 weeks of age in lower turns and 6 and 8 weeks in all turns. Cochlear electrical stimulation induced Fos immunoreactive staining in the nucleus of auditory brain stem neurons in treatment and control groups. A significantly greater number of Fos immunoreactive neurons was found in the contralateral central nucleus of inferior colliculus in 5, 6 and 8 week old deafened animals compared to age-matched controls. The increases were larger with a longer duration of deafness. These results suggest that there are changes in auditory processing as a consequence of neonatal deafness. | en_US |
dc.format.extent | 440886 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Neuroradiology | en_US |
dc.title | Neonatal deafening causes changes in Fos protein induced by cochlear electrical stimulation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationother | Department of Forensic Medicine, Defense Medical College, Tokyo, Japan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 14724378 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47464/1/11068_2004_Article_5253210.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/B:NEUR.0000011329.64948.82 | en_US |
dc.identifier.source | Journal of Neurocytology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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