Lingual deficits in neurotrophin double knockout mice
dc.contributor.author | Nosrat, Irina V. | en_US |
dc.contributor.author | Agerman, Karin | en_US |
dc.contributor.author | Marinescu, Andrea | en_US |
dc.contributor.author | Ernfors, Patrik | en_US |
dc.contributor.author | Nosrat, Christopher A. | en_US |
dc.date.accessioned | 2006-09-11T19:00:34Z | |
dc.date.available | 2006-09-11T19:00:34Z | |
dc.date.issued | 2004-12 | en_US |
dc.identifier.citation | Nosrat, Irina V.; Agerman, Karin; Marinescu, Andrea; Ernfors, Patrik; Nosrat, Christopher A.; (2004). "Lingual deficits in neurotrophin double knockout mice." Journal of Neurocytology 33(6): 607-615. <http://hdl.handle.net/2027.42/47465> | en_US |
dc.identifier.issn | 0300-4864 | en_US |
dc.identifier.issn | 1573-7381 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47465 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16217617&dopt=citation | en_US |
dc.description.abstract | Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae. BDNF null-mutated mice exhibit specific impairments related to innervation and development of the gustatory system while NT-3 null mice have deficits in their lingual somatosensory innervation. To further evaluate the functional specificity of these neurotrophins in the peripheral gustatory system, we generated double BDNF/NT-3 knockout mice and compared the phenotype to BDNF −/− and wild-type mice. Taste papillae morphology was severely distorted in BDNF −/− x NT-3 −/− mice compared to single BDNF −/− and wild-type mice. The deficits were found throughout the tongue and all gustatory papillae. There was a significant loss of fungiform papillae and the papillae were smaller in size compared to BDNF −/− and wild-type mice. Circumvallate papillae in the double knockouts were smaller and did not contain any intraepithelial nerve fibers. BDNF −/− x NT-3 −/− mice exhibited additive losses in both somatosensory and gustatory innervation indicating that BDNF and NT-3 exert specific roles in the innervation of the tongue. However, the additional loss of fungiform papillae and taste buds in BDNF −/− x NT-3 −/− mice compared to single BDNF knockout mice indicate a synergistic functional role for both BDNF-dependent gustatory and NT-3-dependent somatosensory innervations in taste bud and taste papillae innervation and development. | en_US |
dc.format.extent | 741288 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science + Business Media, Inc. | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Neuroradiology | en_US |
dc.title | Lingual deficits in neurotrophin double knockout mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, , University of Michigan, , , Ann Arbor, , MI, , 48109, | en_US |
dc.contributor.affiliationum | Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, , University of Michigan, , , Ann Arbor, , MI, , 48109, | en_US |
dc.contributor.affiliationum | Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, , University of Michigan, , , Ann Arbor, , MI, , 48109, | en_US |
dc.contributor.affiliationother | Unit of Molecular Neurobiology, MBB, , Karolinska Institutet, , , 17177, , Stockholm, , Sweden, | en_US |
dc.contributor.affiliationother | Unit of Molecular Neurobiology, MBB, , Karolinska Institutet, , , 17177, , Stockholm, , Sweden, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16217617 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47465/1/11068_2005_Article_3330.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s11068-005-3330-2 | en_US |
dc.identifier.source | Journal of Neurocytology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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