Developmental analysis of a temperature-sensitive melanotic tumor mutant in Drosophila melanogaster
dc.contributor.author | Rizki, Tahir M. | en_US |
dc.contributor.author | Rizki, Rose M. | en_US |
dc.date.accessioned | 2006-09-11T19:03:28Z | |
dc.date.available | 2006-09-11T19:03:28Z | |
dc.date.issued | 1980-10 | en_US |
dc.identifier.citation | Rizki, T. M.; Rizki, Rose M.; (1980). "Developmental analysis of a temperature-sensitive melanotic tumor mutant in Drosophila melanogaster ." Wilhelm Roux's Archives of Developmental Biology 189(3): 197-206. <http://hdl.handle.net/2027.42/47507> | en_US |
dc.identifier.issn | 1432-041X | en_US |
dc.identifier.issn | 0340-0794 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47507 | |
dc.description.abstract | A sex-linked, temperature-sensitive melanotic tumor mutation in Drosophila melanogaster, tu (1) Sz ts , was mapped at 34.3±and localized to bands 10A10-11 of the polytene chromosomes. At 26°C tu-Sz ts larvae develop melanotic tumors whereas 18°C is non-permissive for tumor formation. Tumorigenesis at 26°C involves the encapsulation of abnormal caudal fat body regions by precociously differentiated hemocytes. Low temperature blocks the development of the abnormal adipose cells and the overlying aberrant tissue surfaces but does not inhibit precocious differentiation of the hemocytes to the lamellocytic form. This phenotypic difference at the two temperatures indicates that lamellocyte encapsulation to form melanotic tumors is directed against abnormal tissue surfaces. On the basis of these observations and an earlier study (Rizki and Rizki 1979) we propose that hereditary melanotic tumors in D. melanogaster are a calss of autoimmune disorders in which affected tissue surfaces arouse the body's cellmediated defense response. | en_US |
dc.format.extent | 5058874 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Melanotic Tumors | en_US |
dc.subject.other | Temperature-sensitive Mutant | en_US |
dc.subject.other | Cell-mediated Defense | en_US |
dc.subject.other | Hemocytes | en_US |
dc.subject.other | Fat Body | en_US |
dc.subject.other | Autoimmunity | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Developmental Biology | en_US |
dc.subject.other | Cell Biology | en_US |
dc.title | Developmental analysis of a temperature-sensitive melanotic tumor mutant in Drosophila melanogaster | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Biological Sciences, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Biological Sciences, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47507/1/427_2004_Article_BF00868678.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00868678 | en_US |
dc.identifier.source | Wilhelm Roux's Archives of Developmental Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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