Effect of dopamine agonist medication on prolactin producing pituitary adenomas
dc.contributor.author | Kovacs, Kalman | en_US |
dc.contributor.author | Stefaneanu, Lucia | en_US |
dc.contributor.author | Horvath, Eva | en_US |
dc.contributor.author | Lloyd, Ricardo V. | en_US |
dc.contributor.author | Lancranjan, I. | en_US |
dc.contributor.author | Fahlbusch, R. | en_US |
dc.contributor.author | Buchfelder, M. | en_US |
dc.date.accessioned | 2006-09-11T19:04:12Z | |
dc.date.available | 2006-09-11T19:04:12Z | |
dc.date.issued | 1991-09 | en_US |
dc.identifier.citation | Kovacs, K.; Stefaneanu, L.; Horvath, E.; Lloyd, R. V.; Lancranjan, I.; Buchfelder, M.; Fahlbusch, R.; (1991). "Effect of dopamine agonist medication on prolactin producing pituitary adenomas." Virchows Archiv A Pathological Anatomy and Histopathology 418(5): 439-446. <http://hdl.handle.net/2027.42/47517> | en_US |
dc.identifier.issn | 1432-2307 | en_US |
dc.identifier.issn | 0174-7398 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47517 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2035258&dopt=citation | en_US |
dc.description.abstract | Conventional light microscopy, immunocyto-chemistry, electron microscopy and in situ hybridization were used to evaluate the effect of dopamine agonists (bromocriptine-LAR and bromocriptine) on the morphology of surgically removed prolactin (PRL)-producing pituitary adenomas. Dopamine agonist therapy resulted in decrease of serum PRL, clinical improvement and tumour shrinkage. Using light and electron microscopy cellular atrophy, interstitial and perivascular fibrosis were noted; in several tumours connective tissue accumulation was pronounced. The cellular response was not uniform. In some adenomas populations of large cells and small cells were distinguished. The large cells contained immunoreactive PRL and expressed the PRL gene indicating resistance to dopamine agonists. It appears that these cells retained the potential to secrete PRL and proliferate despite exposure to dopamine agonists. In the small cells, PRL immunoreactivity and PRL gene expression decreased providing evidence that both PRL release and synthesis were blocked. Small cells can persist in tumours after discontinuation of dopamine agonist medication suggesting these small cells are irreversibly suppressed and are not capable of regaining their endocrine function and proliferative capability. The formation of irreversibly suppressed PRL cells may explain why some PRL-producing adenomas do not recur after withdrawal of dopamine agonists. | en_US |
dc.format.extent | 2301330 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Bromocriptine | en_US |
dc.subject.other | Pathology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Pituitary Neoplasm | en_US |
dc.subject.other | Ultrastructure | en_US |
dc.subject.other | Prolactin | en_US |
dc.title | Effect of dopamine agonist medication on prolactin producing pituitary adenomas | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Division of Neuroendocrinology, Sandoz Pharmaceutical, Basel, Switzerland | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Federal Republic of Germany | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Federal Republic of Germany | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2035258 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47517/1/428_2005_Article_BF01605931.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01605931 | en_US |
dc.identifier.source | Virchows Archiv A Pathological Anatomy and Histopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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