Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui
dc.contributor.author | Ten Eyck, Gary R. | en_US |
dc.contributor.author | Summers, Cliff H. | en_US |
dc.contributor.author | Chinn, Alison F. | en_US |
dc.contributor.author | Jermakowicz, Walter J. | en_US |
dc.date.accessioned | 2006-09-11T19:04:49Z | |
dc.date.available | 2006-09-11T19:04:49Z | |
dc.date.issued | 2005-10 | en_US |
dc.identifier.citation | Ten Eyck, Gary R.; Jermakowicz, Walter J.; Chinn, Alison F.; Summers, Cliff H.; (2005). "Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui ." Anatomy and Embryology 210(3): 221-233. <http://hdl.handle.net/2027.42/47526> | en_US |
dc.identifier.issn | 0340-2061 | en_US |
dc.identifier.issn | 1432-0568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47526 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16151854&dopt=citation | en_US |
dc.description.abstract | Embryonic development of the central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui , was determined by using immunocytochemistry. The majority of anuran amphibians (frogs) possess a larval stage (tadpole) that undergoes metamorphosis, a dramatic post-embryonic event, whereby the tadpole transforms into the adult phenotype. Directly developing frogs have evolved a derived life-history mode where the tadpole stage has been deleted and embryos develop directly into the adult bauplan. Embryonic development in E. coqui is classified into 15 stages (TS 1–15; 1 = oviposition / 15 = hatching). Serotonergic immunoreactivity was initially detected at TS 6 in the raphe nuclei in the developing rhombencephalon. At TS 7, immunopositive perikarya were observed in the paraventricular organ in the hypothalamus and reticular nuclei in the hindbrain. Development of the serotonergic system was steady and gradual during mid-embryogenesis. However, starting at TS 13 there was a substantial increase in the number of serotonergic neurons in the paraventricular, raphe, and reticular nuclei, a large increase in the number of varicose fibers, and a differentiation of the reticular nuclei in the hindbrain. Consequentially, E. coqui displayed a well-developed central serotonergic system prior to hatching (TS 15). In comparison, the serotonergic system in metamorphic frogs typically starts to develop earlier but the surge of development that transpires in this system occurs post-embryonically, during metamorphosis, and not in the latter stages of embryogenesis, as it does in E. coqui . Overall, the serotonergic development in E. coqui is similar to the other vertebrates. | en_US |
dc.format.extent | 781038 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Direct Development | en_US |
dc.subject.other | Amphibian | en_US |
dc.subject.other | Immunocytochemistry | en_US |
dc.subject.other | Development | en_US |
dc.subject.other | 5-Hydroxytryptamine | en_US |
dc.title | Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, Biopsychology Area, The University of Michigan, Ann Arbor, MI, 48109-1109, USA, ; Department of Biological Sciences, Idaho State University, Pocatello, ID, 83209-8007, USA, | en_US |
dc.contributor.affiliationother | Department of Biology, The University of South Dakota, Vermillion, SD, 57069, USA, | en_US |
dc.contributor.affiliationother | Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, 37240, USA, | en_US |
dc.contributor.affiliationother | Department of Biology and Neuroscience Group, Division of Basic Biomedical Sciences, School of Medicine, The University of South Dakota, Vermillion, SD, 57069, USA, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16151854 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47526/1/429_2005_Article_22.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00429-005-0022-8 | en_US |
dc.identifier.source | Anatomy and Embryology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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