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Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui

dc.contributor.authorTen Eyck, Gary R.en_US
dc.contributor.authorSummers, Cliff H.en_US
dc.contributor.authorChinn, Alison F.en_US
dc.contributor.authorJermakowicz, Walter J.en_US
dc.date.accessioned2006-09-11T19:04:49Z
dc.date.available2006-09-11T19:04:49Z
dc.date.issued2005-10en_US
dc.identifier.citationTen Eyck, Gary R.; Jermakowicz, Walter J.; Chinn, Alison F.; Summers, Cliff H.; (2005). "Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui ." Anatomy and Embryology 210(3): 221-233. <http://hdl.handle.net/2027.42/47526>en_US
dc.identifier.issn0340-2061en_US
dc.identifier.issn1432-0568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47526
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16151854&dopt=citationen_US
dc.description.abstractEmbryonic development of the central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui , was determined by using immunocytochemistry. The majority of anuran amphibians (frogs) possess a larval stage (tadpole) that undergoes metamorphosis, a dramatic post-embryonic event, whereby the tadpole transforms into the adult phenotype. Directly developing frogs have evolved a derived life-history mode where the tadpole stage has been deleted and embryos develop directly into the adult bauplan. Embryonic development in E. coqui is classified into 15 stages (TS 1–15; 1 = oviposition / 15 = hatching). Serotonergic immunoreactivity was initially detected at TS 6 in the raphe nuclei in the developing rhombencephalon. At TS 7, immunopositive perikarya were observed in the paraventricular organ in the hypothalamus and reticular nuclei in the hindbrain. Development of the serotonergic system was steady and gradual during mid-embryogenesis. However, starting at TS 13 there was a substantial increase in the number of serotonergic neurons in the paraventricular, raphe, and reticular nuclei, a large increase in the number of varicose fibers, and a differentiation of the reticular nuclei in the hindbrain. Consequentially, E. coqui displayed a well-developed central serotonergic system prior to hatching (TS 15). In comparison, the serotonergic system in metamorphic frogs typically starts to develop earlier but the surge of development that transpires in this system occurs post-embryonically, during metamorphosis, and not in the latter stages of embryogenesis, as it does in E. coqui . Overall, the serotonergic development in E. coqui is similar to the other vertebrates.en_US
dc.format.extent781038 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherDirect Developmenten_US
dc.subject.otherAmphibianen_US
dc.subject.otherImmunocytochemistryen_US
dc.subject.otherDevelopmenten_US
dc.subject.other5-Hydroxytryptamineen_US
dc.titleOntogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coquien_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, Biopsychology Area, The University of Michigan, Ann Arbor, MI, 48109-1109, USA, ; Department of Biological Sciences, Idaho State University, Pocatello, ID, 83209-8007, USA,en_US
dc.contributor.affiliationotherDepartment of Biology, The University of South Dakota, Vermillion, SD, 57069, USA,en_US
dc.contributor.affiliationotherNeuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, 37240, USA,en_US
dc.contributor.affiliationotherDepartment of Biology and Neuroscience Group, Division of Basic Biomedical Sciences, School of Medicine, The University of South Dakota, Vermillion, SD, 57069, USA,en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16151854en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47526/1/429_2005_Article_22.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00429-005-0022-8en_US
dc.identifier.sourceAnatomy and Embryologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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