Cytological changes related to Brucella canis variants uptake in vitro
dc.contributor.author | Eveland, W. C. | en_US |
dc.contributor.author | Egwu, Igbo N. | en_US |
dc.date.accessioned | 2006-09-11T19:05:02Z | |
dc.date.available | 2006-09-11T19:05:02Z | |
dc.date.issued | 1979-05 | en_US |
dc.identifier.citation | Egwu, Igbo N.; Eveland, Warren C.; (1979). "Cytological changes related to Brucella canis variants uptake in vitro." Medical Microbiology and Immunology 167(2): 107-115. <http://hdl.handle.net/2027.42/47529> | en_US |
dc.identifier.issn | 1432-1831 | en_US |
dc.identifier.issn | 0300-8584 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47529 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=112368&dopt=citation | en_US |
dc.description.abstract | In this study, evidence for in vitro uptake, invasion, and cytopathogonomic effects of normal and variant strains of B. canis on tissue culture, is presented. B. canis L-phase were penicillin-induced and these microorganisms produced revertants on penicillin-free media. Tissue culture (LLC-MK 2 ) cells were divided into different normal and variant-infected groups (I–IV), including controls. Bright-field and electron microscopic observations indicated uptake of all the strains and recognizable host cell damage (CPE) to varying degrees. At 72 h after infection, the extent of damage by L-phase was the least (55.5% CPE). The L-phase-derived revertants resulted in 80% damage; this approximates the adverse effect of normal B. canis (85%). In addition to these gross changes, various structural abnormalities, including pyknosis, nuclear disorganization, vacuolation, and karyorrhexis, were apparent. The implications of these findings and the indirect role of the L-phase in brucellosis due to B. canis are discussed. | en_US |
dc.format.extent | 1365054 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.title | Cytological changes related to Brucella canis variants uptake in vitro | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medical Technology, SUNYAB Clinical Center, State University of New York at Buffalo, Building AA - Room 107, 462 Grider Street, 14215, Buffalo, NY, USA; The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Medical Technology, SUNYAB Clinical Center, State University of New York at Buffalo, Building AA - Room 107, 462 Grider Street, 14215, Buffalo, NY, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 112368 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47529/1/430_2005_Article_BF02123560.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02123560 | en_US |
dc.identifier.source | Medical Microbiology and Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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