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The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy

dc.contributor.authorBrewer, George J.en_US
dc.contributor.authorSmouse, Peter E.en_US
dc.contributor.authorOelshlegel, F. J.en_US
dc.contributor.authorShore, S. H.en_US
dc.contributor.authorKruckeberg, Walter C.en_US
dc.date.accessioned2006-09-11T19:05:45Z
dc.date.available2006-09-11T19:05:45Z
dc.date.issued1977-06en_US
dc.identifier.citationKruckeberg, W. C.; Oelshlegel, F. J.; Shore, S. H.; Smouse, P. E.; Brewer, G. J.; (1977). "The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy." Research in Experimental Medicine 170(2): 149-159. <http://hdl.handle.net/2027.42/47537>en_US
dc.identifier.issn0300-9130en_US
dc.identifier.issn1433-8580en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47537
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=882712&dopt=citationen_US
dc.description.abstractThe objective of these studies is to define the role of zinc in RBC ghost morphology specifically in comparison to the echinocytogenic effects of calcium. Erythrocyte ghosts were prepared from patients with sickle cell anemia, treated with zinc and/or calcium and the resulting cell morphology studied by scanning electron microscopy. Our results showed that zinc consistently and significantly antagonized the echinocytogenic effect of calcium. A simple log linear statistical model was used to evaluate the data and supported this conclusion. We discuss the potential significance of these findings to the effect of zinc treatment on patients with sickle cell anemia.en_US
dc.format.extent780853 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherSickle Cell Anemiaen_US
dc.subject.otherZincen_US
dc.subject.otherCalciumen_US
dc.subject.otherElectron Microscopyen_US
dc.subject.otherErythrocyteen_US
dc.subject.otherEchinocyteen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherMedicine & Public Healthen_US
dc.titleThe effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA; Department of Preventive Medicine, University of Mississippi Medical Center Jackson, 39216, Mississippi, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid882712en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47537/1/433_2005_Article_BF01851386.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF01851386en_US
dc.identifier.sourceResearch in Experimental Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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