The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Smouse, Peter E. | en_US |
dc.contributor.author | Oelshlegel, F. J. | en_US |
dc.contributor.author | Shore, S. H. | en_US |
dc.contributor.author | Kruckeberg, Walter C. | en_US |
dc.date.accessioned | 2006-09-11T19:05:45Z | |
dc.date.available | 2006-09-11T19:05:45Z | |
dc.date.issued | 1977-06 | en_US |
dc.identifier.citation | Kruckeberg, W. C.; Oelshlegel, F. J.; Shore, S. H.; Smouse, P. E.; Brewer, G. J.; (1977). "The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy." Research in Experimental Medicine 170(2): 149-159. <http://hdl.handle.net/2027.42/47537> | en_US |
dc.identifier.issn | 0300-9130 | en_US |
dc.identifier.issn | 1433-8580 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47537 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=882712&dopt=citation | en_US |
dc.description.abstract | The objective of these studies is to define the role of zinc in RBC ghost morphology specifically in comparison to the echinocytogenic effects of calcium. Erythrocyte ghosts were prepared from patients with sickle cell anemia, treated with zinc and/or calcium and the resulting cell morphology studied by scanning electron microscopy. Our results showed that zinc consistently and significantly antagonized the echinocytogenic effect of calcium. A simple log linear statistical model was used to evaluate the data and supported this conclusion. We discuss the potential significance of these findings to the effect of zinc treatment on patients with sickle cell anemia. | en_US |
dc.format.extent | 780853 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Sickle Cell Anemia | en_US |
dc.subject.other | Zinc | en_US |
dc.subject.other | Calcium | en_US |
dc.subject.other | Electron Microscopy | en_US |
dc.subject.other | Erythrocyte | en_US |
dc.subject.other | Echinocyte | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | The effects of zinc on the morphology of sickle red blood cell ghosts as observed by scanning electron microscopy | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 E. Catherine Street, 48109, Ann Arbor, Michigan, USA; Department of Preventive Medicine, University of Mississippi Medical Center Jackson, 39216, Mississippi, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 882712 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47537/1/433_2005_Article_BF01851386.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01851386 | en_US |
dc.identifier.source | Research in Experimental Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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