Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
dc.contributor.author | Isaacs, William B. | en_US |
dc.contributor.author | Cooney, Kathleen A. | en_US |
dc.contributor.author | Wiley, Kathleen E. | en_US |
dc.contributor.author | Trent, Jeffrey M. | en_US |
dc.contributor.author | Dimitrov, Latchezar | en_US |
dc.contributor.author | Chang, Bao-Li | en_US |
dc.contributor.author | Lange, Ethan M. | en_US |
dc.contributor.author | Suh, Edward | en_US |
dc.contributor.author | Gillanders, Elizabeth M. | en_US |
dc.contributor.author | Lange, Leslie A. | en_US |
dc.contributor.author | Xu, Jianfeng | en_US |
dc.contributor.author | Valis, Christopher J. | en_US |
dc.contributor.author | Baffoe-Bonnie, Agnes B. | en_US |
dc.contributor.author | Zheng, S. Lilly | en_US |
dc.contributor.author | Fredriksson, Henna | en_US |
dc.contributor.author | Matikainen, Mika P. | en_US |
dc.contributor.author | Gronberg, Henrik | en_US |
dc.contributor.author | Tammela, Teuvo L. J. | en_US |
dc.contributor.author | Bailey-Wilson, Joan E. | en_US |
dc.contributor.author | Walsh, Patrick C. | en_US |
dc.contributor.author | Schleutker, Johanna | en_US |
dc.contributor.author | Ikonen, Tarja | en_US |
dc.contributor.author | Langefeld, Carl D. | en_US |
dc.contributor.author | Isaacs, Sarah D. | en_US |
dc.contributor.author | Wiklund, Fredrik | en_US |
dc.date.accessioned | 2006-09-11T19:10:18Z | |
dc.date.available | 2006-09-11T19:10:18Z | |
dc.date.issued | 2006-02 | en_US |
dc.identifier.citation | Chang, Bao-Li; Lange, Ethan M.; Dimitrov, Latchezar; Valis, Christopher J.; Gillanders, Elizabeth M.; Lange, Leslie A.; Wiley, Kathleen E.; Isaacs, Sarah D.; Wiklund, Fredrik; Baffoe-Bonnie, Agnes; Langefeld, Carl D; Zheng, S. Lilly; Matikainen, Mika P.; Ikonen, Tarja; Fredriksson, Henna; Tammela, Teuvo; Walsh, Patrick C.; Bailey-Wilson, Joan E.; Schleutker, Johanna; Gronberg, Henrik; Cooney, Kathleen A.; Isaacs, William B.; Suh, Edward; Trent, Jeffrey M.; Xu, Jianfeng; (2006). "Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect." Human Genetics 118(6): 716-724. <http://hdl.handle.net/2027.42/47598> | en_US |
dc.identifier.issn | 1432-1203 | en_US |
dc.identifier.issn | 0340-6717 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47598 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16328469&dopt=citation | en_US |
dc.description.abstract | Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility genes. Segregation analyses of prostate cancer suggest that a multigene model may best explain familial clustering of this disease. Therefore, modeling gene–gene interactions in linkage analysis may improve the power to detect chromosomal regions harboring these disease susceptibility genes. In this study, we systematically screened for prostate cancer linkage by modeling two-locus gene–gene interactions for all possible pairs of loci across the genome in 426 prostate cancer families from Johns Hopkins Hospital, University of Michigan, University of Umeå, and University of Tampere. We found suggestive evidence for an epistatic interaction for six sets of loci (target chromosome-wide/reference marker-specific P ≤0.0001). Evidence for these interactions was found in two independent subsets from within the 426 families. While the validity of these results requires confirmation from independent studies and the identification of the specific genes underlying this linkage evidence, our approach of systematically assessing gene–gene interactions across the entire genome represents a promising alternative approach for gene identification for prostate cancer. | en_US |
dc.format.extent | 380006 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.title | Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine and Urology, University of Michigan, Ann Arbor, MI, USA, | en_US |
dc.contributor.affiliationother | Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA, | en_US |
dc.contributor.affiliationother | Department of Genetics, University of North Carolina, Chapel Hill, NC, USA, | en_US |
dc.contributor.affiliationother | Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | Department of Genetics, University of North Carolina, Chapel Hill, NC, USA, ; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA, | en_US |
dc.contributor.affiliationother | Translational Genomics Research Institute (TGen), Phoenix, AZ, USA, | en_US |
dc.contributor.affiliationother | Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | Translational Genomics Research Institute (TGen), Phoenix, AZ, USA, | en_US |
dc.contributor.affiliationother | Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | National Human Genome Research Institute, National Institute of Health, Bethesda, MD, USA, | en_US |
dc.contributor.affiliationother | Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA, ; Translational Genomics Research Institute (TGen), Phoenix, AZ, USA, ; Medical Center Blvd, Winston-Salem, NC, 27157, USA, ; Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, | en_US |
dc.contributor.affiliationother | Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, | en_US |
dc.contributor.affiliationother | Department of Urology, University of Tampere and Tampere University Hospital, Tampere, Finland, | en_US |
dc.contributor.affiliationother | Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, | en_US |
dc.contributor.affiliationother | Department of Radiation Sciences, Oncology, University of Umeå, Umeå, Sweden, | en_US |
dc.contributor.affiliationother | Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA, | en_US |
dc.contributor.affiliationother | National Human Genome Research Institute, National Institute of Health, Bethesda, MD, USA, | en_US |
dc.contributor.affiliationother | Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA, | en_US |
dc.contributor.affiliationother | Department of Urology, University of Tampere and Tampere University Hospital, Tampere, Finland, ; Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, | en_US |
dc.contributor.affiliationother | Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA, | en_US |
dc.contributor.affiliationother | Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA, | en_US |
dc.contributor.affiliationother | Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA, | en_US |
dc.contributor.affiliationother | Department of Radiation Sciences, Oncology, University of Umeå, Umeå, Sweden, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16328469 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47598/1/439_2005_Article_99.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00439-005-0099-4 | en_US |
dc.identifier.source | Human Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.