Show simple item record

Possible cases of relaxed selection in civilized populations

dc.contributor.authorPost, Richard H.en_US
dc.date.accessioned2006-09-11T19:10:33Z
dc.date.available2006-09-11T19:10:33Z
dc.date.issued1971-12en_US
dc.identifier.citationPost, R. H.; (1971). "Possible cases of relaxed selection in civilized populations." Human Genetics 13(4): 253-284. <http://hdl.handle.net/2027.42/47601>en_US
dc.identifier.issn0340-6717en_US
dc.identifier.issn1432-1203en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47601
dc.description.abstractGenetic traits which are disadvantageous or deleterious in “primitive” cultures, of hunters and food gatherers, have very low frequencies in almost all cases. There are a few special exceptions, such as the sickle cell trait. Some deleterious traits under genetic control are rare in “primitive” populations but have fairly high frequencies in populations with long histories or prehistories of “civilization”, such as Chinese, Japanese or European populations. The Darwinist might suggest that these traits have less selective disadvantage, that is, lower rates of selective elimination, in “civilized” habitats; i.e. that the various changes in habitat accompanying “civilization” have caused the rigor of natural selection to relax, in part or perhaps completely. Several cases are discussed of traits under genetic control or genetic influence which demonstrate this phenomenal contrast, between low frequencies among “primitive” populations and high frequencies among “civilized” populations. Population data are presented for 4 such cases: colorblindness, myopia, abnormality of the nasal septum and abnormally small external opening of the tear duct. Mit einigen bekannten Ausnahmen, z. B. Sichelzellanämie, kommen genetische Merkmale, die bei den Urvölkern von Jägern und Sammlern ungünstig oder sogar schädlich wirkten, mit niedriger Häufigkeit vor. Genetisch bedingte schädliche Merkmale, die selten unter Urvölkern gefunden werden, kommen jedoch häufiger vor bei Bevölkerungen, die eine lange Geschichte bzw. Vorgeschichte der “Zivilisation” besitzen, wie z. B. in China, Japan oder Europa. Ein Darwinist würde behaupten, daß bei “zivilisierten” Wohnorten solche Merkmale selektiv weniger nachteilig wirken, d. h., daß die selektive Ausscheidung langsamer vorgeht. Anders gesagt: der mit der “Zivilisation” verbundene Wechsel des Wohnortes bildet einen Grund für eine Milderung der Strenge der natürlichen Auslese.en_US
dc.format.extent2378436 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherMolecular Medicineen_US
dc.subject.otherHuman Geneticsen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherMetabolic Diseasesen_US
dc.titlePossible cases of relaxed selection in civilized populationsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48104, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47601/1/439_2004_Article_BF00273943.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00273943en_US
dc.identifier.sourceHuman Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.