Possible cases of relaxed selection in civilized populations
dc.contributor.author | Post, Richard H. | en_US |
dc.date.accessioned | 2006-09-11T19:10:33Z | |
dc.date.available | 2006-09-11T19:10:33Z | |
dc.date.issued | 1971-12 | en_US |
dc.identifier.citation | Post, R. H.; (1971). "Possible cases of relaxed selection in civilized populations." Human Genetics 13(4): 253-284. <http://hdl.handle.net/2027.42/47601> | en_US |
dc.identifier.issn | 0340-6717 | en_US |
dc.identifier.issn | 1432-1203 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47601 | |
dc.description.abstract | Genetic traits which are disadvantageous or deleterious in “primitive” cultures, of hunters and food gatherers, have very low frequencies in almost all cases. There are a few special exceptions, such as the sickle cell trait. Some deleterious traits under genetic control are rare in “primitive” populations but have fairly high frequencies in populations with long histories or prehistories of “civilization”, such as Chinese, Japanese or European populations. The Darwinist might suggest that these traits have less selective disadvantage, that is, lower rates of selective elimination, in “civilized” habitats; i.e. that the various changes in habitat accompanying “civilization” have caused the rigor of natural selection to relax, in part or perhaps completely. Several cases are discussed of traits under genetic control or genetic influence which demonstrate this phenomenal contrast, between low frequencies among “primitive” populations and high frequencies among “civilized” populations. Population data are presented for 4 such cases: colorblindness, myopia, abnormality of the nasal septum and abnormally small external opening of the tear duct. Mit einigen bekannten Ausnahmen, z. B. Sichelzellanämie, kommen genetische Merkmale, die bei den Urvölkern von Jägern und Sammlern ungünstig oder sogar schädlich wirkten, mit niedriger Häufigkeit vor. Genetisch bedingte schädliche Merkmale, die selten unter Urvölkern gefunden werden, kommen jedoch häufiger vor bei Bevölkerungen, die eine lange Geschichte bzw. Vorgeschichte der “Zivilisation” besitzen, wie z. B. in China, Japan oder Europa. Ein Darwinist würde behaupten, daß bei “zivilisierten” Wohnorten solche Merkmale selektiv weniger nachteilig wirken, d. h., daß die selektive Ausscheidung langsamer vorgeht. Anders gesagt: der mit der “Zivilisation” verbundene Wechsel des Wohnortes bildet einen Grund für eine Milderung der Strenge der natürlichen Auslese. | en_US |
dc.format.extent | 2378436 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Molecular Medicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Metabolic Diseases | en_US |
dc.title | Possible cases of relaxed selection in civilized populations | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48104, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47601/1/439_2004_Article_BF00273943.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00273943 | en_US |
dc.identifier.source | Human Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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