Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese
dc.contributor.author | Rosenblum, Barnett B. | en_US |
dc.contributor.author | Neel, James V. | en_US |
dc.contributor.author | Asakawa, Jun-ichi | en_US |
dc.contributor.author | Takahashi, Norio | en_US |
dc.date.accessioned | 2006-09-11T19:11:37Z | |
dc.date.available | 2006-09-11T19:11:37Z | |
dc.date.issued | 1985-07 | en_US |
dc.identifier.citation | Asakawa, Jun-ichi; Takahashi, Norio; Rosenblum, Barnett B.; Neel, James V.; (1985). "Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese." Human Genetics 70(3): 222-230. <http://hdl.handle.net/2027.42/47615> | en_US |
dc.identifier.issn | 1432-1203 | en_US |
dc.identifier.issn | 0340-6717 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47615 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4018789&dopt=citation | en_US |
dc.description.abstract | Genetic variation has been studied in plasma samples from 107 Amerindian children and their parents, and 110 Japanese children and their parents by means of two-dimensional polyacrylamide gel electrophoresis. Twenty-three polypeptides were scored; the identity of nine of these is at present still unknown. Genetic variation was encountered in 11 of these polypeptides. We have previously reported that the index of heterozygosity was 6.2±0.7% for 20 “randomly selected”, silver stained polypeptides scored for genetic variation in Caucasoids (Rosenblum et al. 1983b). For technical reasons only 11 of these 20 polypeptides could be routinely scored in preparations from the Amerindian samples. For these 11 polypeptides, the indices of heterozygosity in the three populations were: Amerindians, 4.5±0.6%; Japanese, 5.7±0.7%; Caucasoids, 8.0±1.1%. Even with these relatively small numbers some striking ethnic differences as regards individual polypeptides are apparent. | en_US |
dc.format.extent | 1453822 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Molecular Medicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Metabolic Diseases | en_US |
dc.title | Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Division of Biochemical Genetics, Department of Clinical Laboratories, Radiation Effects Research Foundation, 730, Hiroshima, Japan | en_US |
dc.contributor.affiliationother | Division of Biochemical Genetics, Department of Clinical Laboratories, Radiation Effects Research Foundation, 730, Hiroshima, Japan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4018789 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47615/1/439_2004_Article_BF00273446.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00273446 | en_US |
dc.identifier.source | Human Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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