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Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8

dc.contributor.authorRomeo, Giovannien_US
dc.contributor.authorDean, Michaelen_US
dc.contributor.authorLynch, Jenniferen_US
dc.contributor.authorAmos, Jean A.en_US
dc.contributor.authorFerrari, Maurizioen_US
dc.contributor.authorHalley, Dickyen_US
dc.contributor.authorRusso, Silviaen_US
dc.contributor.authorFinn, Paula B.en_US
dc.contributor.authorIannuzzi, Michael C.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.contributor.authorDevoto, Marcellaen_US
dc.contributor.authorOostra, Benen_US
dc.contributor.authorWeir, Bruce S.en_US
dc.contributor.authorWard, Kenen_US
dc.date.accessioned2006-09-11T19:12:27Z
dc.date.available2006-09-11T19:12:27Z
dc.date.issued1990-08en_US
dc.identifier.citationDean, Michael; Amos, Jean A.; Lynch, Jennifer; Romeo, Giovanni; Devoto, Marcella; Ward, Ken; Halley, Dicky; Oostra, Ben; Ferrari, Maurizio; Russo, Silvia; Weir, Bruce S.; Finn, Paula B.; Collins, Francis S.; Iannuzzi, Michael C.; (1990). "Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8." Human Genetics 85(3): 275-278. <http://hdl.handle.net/2027.42/47627>en_US
dc.identifier.issn1432-1203en_US
dc.identifier.issn0340-6717en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47627
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1975555&dopt=citationen_US
dc.description.abstractThree polymorphic DNA markers surrounding the D7S8 locus were tested for their usefulness in the diagnosis of cystic fibrosis (CF) by linkage analysis. The markers correspond to the loci D7S424 and D7S426. These polymorphisms were studied by centers in the U.S., the United Kingdom, the Netherlands, and Italy, using samples from populations throughout Europe and North America. The additional information provided by these probes increased the heterogeneity of the region from 50% to 58% and was essential for a completely informative diagnosis in one family. A very high degree of linkage disequilibrium was found between these markers, which span a distance of approximately 250kb. In addition, linkage disequilibrium with CF was noted. Significant heterogeneity of linkage disequilibrium was found among the populations, both for the marker-marker pairs and between the markers and CF.en_US
dc.format.extent393463 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherMolecular Medicineen_US
dc.subject.otherMetabolic Diseasesen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherHuman Geneticsen_US
dc.titlePrenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumUniversity of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherIstituto Giannina Gaslini, I-16148, Genoa, Italyen_US
dc.contributor.affiliationotherIstituto Giannina Gaslini, I-16148, Genoa, Italyen_US
dc.contributor.affiliationotherJohn Radcliffe Hospital, OX3 9DU, Oxford, UKen_US
dc.contributor.affiliationotherProgram Resources Inc., Frederick Cancer Research and Development Center, 21701, Frederick, MD, USAen_US
dc.contributor.affiliationotherBoston University School of Medicine, 02148, Boston, MA, USAen_US
dc.contributor.affiliationotherIstituto Scientificio H. S. Raffaele, I-20132, Milan, Italyen_US
dc.contributor.affiliationotherErasmus University, NL-300, DR Rotterdam, The Netherlandsen_US
dc.contributor.affiliationotherBoston University School of Medicine, 02148, Boston, MA, USAen_US
dc.contributor.affiliationotherIstituto Scientificio H. S. Raffaele, I-20132, Milan, Italyen_US
dc.contributor.affiliationotherNorth Carolina State University, 27695, Raleigh, NC, USAen_US
dc.contributor.affiliationotherErasmus University, NL-300, DR Rotterdam, The Netherlandsen_US
dc.contributor.affiliationotherUniversity of Utah, 84132, Salt Lake City, UT, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid1975555en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47627/1/439_2004_Article_BF00206745.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00206745en_US
dc.identifier.sourceHuman Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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