Neuroregulation of protein synthesis in odontoblasts of the first molar of the rat after wounding
dc.contributor.author | Chiego, Daniel J. | en_US |
dc.contributor.author | Avery, James K. | en_US |
dc.contributor.author | Klein, Robert M. | en_US |
dc.date.accessioned | 2006-09-11T19:16:23Z | |
dc.date.available | 2006-09-11T19:16:23Z | |
dc.date.issued | 1987-04 | en_US |
dc.identifier.citation | Chiego, Daniel J.; Avery, James K.; Klein, Robert M.; (1987). "Neuroregulation of protein synthesis in odontoblasts of the first molar of the rat after wounding." Cell and Tissue Research 248(1): 119-123. <http://hdl.handle.net/2027.42/47683> | en_US |
dc.identifier.issn | 1432-0878 | en_US |
dc.identifier.issn | 0302-766X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47683 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3568111&dopt=citation | en_US |
dc.description.abstract | Odontoblasts respond to occlusal trauma by increased elaboration of a matrix which is subsequently calcified to form reparative dentin. The purpose of the present study was to analyze quantitatively and compare the ability of odontoblasts to synthesize collagen after wounding in rats with an intact innervation (baseline) and in rats with sensory (inferior alveolar nerve, IAN) and/or sympathetic (superior cervical ganglion, SCG) surgical denervation. Surgery was performed 7 days prior to wounding. All rats had 1 mm of enamel and dentin removed from the occlusal surface of the first mandibular molar (resected side) with the contralateral tooth serving as a control. Rats were killed 1 h after injection with 3 H-proline on days 0, 5, 10 or 15 after wounding, and mandibles were removed and processed for autoradiography. Grain counts were performed over odontoblasts throughout the pulp horns for each time period and for control and experimental molars in intact (baseline) and denervated groups. When compared to the control baseline, the experimental baseline data showed increased 3 -proline uptake throughout the study with a peak at 5 days. When compared to the baseline data, IAN and SCG results demonstrated a delay or attenuation of the protein synthetic response. The results indicate that the sensory and sympathetic neural components may regulate odontoblastic response to wounding. | en_US |
dc.format.extent | 567918 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Denervation | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Endocrinology | en_US |
dc.subject.other | Protein Synthesis | en_US |
dc.subject.other | Wound Healing | en_US |
dc.subject.other | Neural Regulation | en_US |
dc.subject.other | Autoradiography | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Odontoblasts | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Rat | en_US |
dc.title | Neuroregulation of protein synthesis in odontoblasts of the first molar of the rat after wounding | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oral Biology, University of Michigan, School of Dentistry, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Oral Biology, University of Michigan, School of Dentistry, Ann Arbor, Michigan, USA; Department of Oral Biology, University of Michigan, School of Dentistry, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Anatomy/Division of Cell Biology, University of Kansas, College of Health Sciences and Hospital, Kansas City, Kansas, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3568111 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47683/1/441_2005_Article_BF01239971.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01239971 | en_US |
dc.identifier.source | Cell and Tissue Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.