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Zymogen granules of mouse parotid acinar cells are acidified in situ in an ATP-dependent manner
dc.contributor.authorLisle, Robert C.en_US
dc.contributor.authorSteinberg, Robinen_US
dc.contributor.authorWilliams, John A.en_US
dc.date.accessioned2006-09-11T19:16:27Z
dc.date.available2006-09-11T19:16:27Z
dc.date.issued1988-07en_US
dc.identifier.citationLisle, Robert C.; Steinberg, Robin; Williams, John A.; (1988). "Zymogen granules of mouse parotid acinar cells are acidified in situ in an ATP-dependent manner." Cell and Tissue Research 253(1): 267-269. <http://hdl.handle.net/2027.42/47684>en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.issn1432-0878en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47684
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3416345&dopt=citationen_US
dc.description.abstractThe mechanism for acidification of zymogen granules in acinar cells of mouse parotid gland was explored using acridine orange, lysosomotropic agents, and an inhibitor of cellular ATP production. Methylamine and monensin reversibly collapsed the pH gradient of granules without affecting cellular ATP levels. Depletion of cellular ATP with antimycin A did not collapse the pH gradient. However, recovery of acidity in the granules, after collapse of the pH gradient by methylamine, was blocked by depletion of cellular ATP. These results demonstrate that zymogen granules of parotid gland are acidic in situ and that ATP is required for acidification of the granules.en_US
dc.format.extent1009549 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherParotid Glanden_US
dc.subject.otherCell Biologyen_US
dc.subject.otherEndocrinologyen_US
dc.subject.otherZymogen Granuleen_US
dc.subject.otherMouse (Swiss Webster)en_US
dc.subject.otherAcridine Orangeen_US
dc.subject.otherNeurologyen_US
dc.subject.otherAcidificationen_US
dc.subject.otherLysosomotropic Agentsen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherNeurosciencesen_US
dc.titleZymogen granules of mouse parotid acinar cells are acidified in situ in an ATP-dependent manneren_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCell Biology Laboratory and Department of Medicine, Mount Zion Hospital, San Francisco, USA; The Departments of Physiology and Medicine, University of California, San Francisco, USA; Department of Physiology, University of Michigan, Medical School, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherCell Biology Laboratory and Department of Medicine, Mount Zion Hospital, San Francisco, USA; The Departments of Physiology and Medicine, University of California, San Francisco, USAen_US
dc.contributor.affiliationotherCell Biology Laboratory and Department of Medicine, Mount Zion Hospital, San Francisco, USA; The Departments of Physiology and Medicine, University of California, San Francisco, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid3416345en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47684/1/441_2004_Article_BF00221764.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00221764en_US
dc.identifier.sourceCell and Tissue Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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