Ornithine decarboxylase activity during development of the mouse inner ear in vivo and in vitro

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dc.contributor.author Crann, Sherry A. en_US
dc.contributor.author Water, Thomas R. en_US
dc.contributor.author Schacht, Jochen en_US
dc.date.accessioned 2006-09-11T19:16:48Z
dc.date.available 2006-09-11T19:16:48Z
dc.date.issued 1991-09 en_US
dc.identifier.citation Crann, Sherry A.; Water, Thomas R.; Schacht, Jochen; (1991). "Ornithine decarboxylase activity during development of the mouse inner ear in vivo and in vitro." Cell and Tissue Research 265(3): 547-550. <http://hdl.handle.net/2027.42/47689> en_US
dc.identifier.issn 0302-766X en_US
dc.identifier.issn 1432-0878 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/47689
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1786595&dopt=citation en_US
dc.description.abstract Ornithine decarboxylase activity was determined during the development of the peripheral auditory system in the murine otocyst with the goal of understanding the role of this enzyme in the morphological and functional maturation of the inner ear. At gestational days 11 and 12 enzyme activity was more than 10-fold higher than adult levels. A sharp decline occured between day 12 and 13 after which activity rose to a peak around day 15. Activity then dropped continuously until near-adult levels were reached at birth. A lower specific activity of ODC but a similar time-course was seen in otocysts explanted at gestational day 13 and subsequently cultured for 6 days. For two stages of development, enzyme activity and binding of 3 H-α-difluoromethylornithine were compared. The four-fold difference in enzymatic activity on gestational days 15 and 17 was paralleled by a similar difference in binding. Ornithine decarboxylase activity during inner ear development therefore seems primarily regulated at the level of protein synthesis. Ornithine decarboxylase activity correlates with major inductive events in the morphogenesis of the cartilagenous otic capsule that serves as a template for the formation of the bony labyrinth. The pattern of activity may reflect the changes in the head mesenchyme that is recruited by the otocyst to aggregate and form its protective otic capsule. en_US
dc.format.extent 471501 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag en_US
dc.subject.other Development, Ontogenic en_US
dc.subject.other Cell Biology en_US
dc.subject.other Biomedicine en_US
dc.subject.other Neurosciences en_US
dc.subject.other Endocrinology en_US
dc.subject.other Ornithine Decarboxylase en_US
dc.subject.other Neurology en_US
dc.subject.other Morphogenesis en_US
dc.subject.other Mesenchyme en_US
dc.subject.other Otocysts en_US
dc.subject.other Ear, Inner en_US
dc.subject.other Mouse (CBAxC57) en_US
dc.title Ornithine decarboxylase activity during development of the mouse inner ear in vivo and in vitro en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Kresge Hearing Research Institute, University of Michigan, 48109-0506, Ann Arbor, MI, USA en_US
dc.contributor.affiliationum Kresge Hearing Research Institute, University of Michigan, 48109-0506, Ann Arbor, MI, USA en_US
dc.contributor.affiliationother Department of Otolaryngology and Department of Neuroscience, Laboratory of Developmental Otobiology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 1786595 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/47689/1/441_2004_Article_BF00340878.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF00340878 en_US
dc.identifier.source Cell and Tissue Research en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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