Potent cytotoxins produced by a microbial symbiont protect host larvae from predation
dc.contributor.author | Lopanik, Nicole | en_US |
dc.contributor.author | Lindquist, Niels | en_US |
dc.contributor.author | Targett, Nancy | en_US |
dc.date.accessioned | 2006-09-11T19:17:46Z | |
dc.date.available | 2006-09-11T19:17:46Z | |
dc.date.issued | 2004-03 | en_US |
dc.identifier.citation | Lopanik, Nicole; Lindquist, Niels; Targett, Nancy; (2004). "Potent cytotoxins produced by a microbial symbiont protect host larvae from predation." Oecologia 139(1): 131-139. <http://hdl.handle.net/2027.42/47703> | en_US |
dc.identifier.issn | 0029-8549 | en_US |
dc.identifier.issn | 1432-1939 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47703 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14747940&dopt=citation | en_US |
dc.description.abstract | Larvae of the sessile marine invertebrate Bugula neritina (Bryozoa) are protected by an effective chemical defense. From the larvae, we isolated three bryostatin-class macrocyclic polyketides, including the novel bryostatin 20, that deterred feeding by a common planktivorous fish that co-occurs with B. neritina . A unique bacterial symbiont of B. neritina , Endobugula sertula , was hypothesized as the putative source of the bryostatins. We show that: (1) bryostatins are concentrated in B. neritina larvae and protect them against predation by fish; (2) the adults are not defended by bryostatins; and (3) E. sertula produces bryostatins. This study represents the first example from the marine environment of a microbial symbiont producing an anti-predator defense for its host and, in this case, specifically for the host’s larval stage, which is exceptionally vulnerable to predators. | en_US |
dc.format.extent | 273420 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Bugula Neritina | en_US |
dc.subject.other | Chemical Defense | en_US |
dc.subject.other | Bryostatins | en_US |
dc.subject.other | Endobugula Sertula | en_US |
dc.subject.other | Symbiosis | en_US |
dc.subject.other | LifeSciences | en_US |
dc.title | Potent cytotoxins produced by a microbial symbiont protect host larvae from predation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Graduate College of Marine Studies, University of Delaware, Lewes, DE 19958, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Institute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, NC 28557, USA | en_US |
dc.contributor.affiliationother | Graduate College of Marine Studies, University of Delaware, Lewes, DE 19958, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 14747940 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47703/1/442_2004_Article_1487.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00442-004-1487-5 | en_US |
dc.identifier.source | Oecologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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