On the orders of magnitude of epigenic dynamics and monoclonal antibody production
dc.contributor.author | Lee, Gyun Min | en_US |
dc.contributor.author | Palsson, Bernhard Ø. | en_US |
dc.contributor.author | Savinell, J. M. | en_US |
dc.date.accessioned | 2006-09-11T19:25:08Z | |
dc.date.available | 2006-09-11T19:25:08Z | |
dc.date.issued | 1989-09 | en_US |
dc.identifier.citation | Savinell, J. M.; Lee, G. M.; Palsson, B. O.; (1989). "On the orders of magnitude of epigenic dynamics and monoclonal antibody production." Bioprocess Engineering 4(5): 231-234. <http://hdl.handle.net/2027.42/47810> | en_US |
dc.identifier.issn | 0178-515X | en_US |
dc.identifier.issn | 1615-7605 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47810 | |
dc.description.abstract | The hybridoma cell's maximum capacity for monoclonal antibody ( MAb ) production is estimated to be 2300–8000 MAb molecules/cell/s, using measured rates of transcription and translation, and the limitations imposed by the size of the polymerase molecule and the ribosome. Nearly all the production rates reported in the literature fall into or below this range of production rates. Data from batch cultures of hybridomas demonstrate a constant specific rate of MAb production until the time integral of the viable cell concentration reaches about 10 8 cells · h/cm 3 . At this point, some essential nutrients from the standard media are depleted, causing MAb production to decline. | en_US |
dc.format.extent | 385959 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Industrial Chemistry/Chemical Engineering | en_US |
dc.subject.other | Waste Management/Waste Technology | en_US |
dc.subject.other | Food Science | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biotechnology | en_US |
dc.subject.other | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | en_US |
dc.title | On the orders of magnitude of epigenic dynamics and monoclonal antibody production | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Herbert H. Dow Building, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Herbert H. Dow Building, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Herbert H. Dow Building, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47810/1/449_2004_Article_BF00369177.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00369177 | en_US |
dc.identifier.source | Bioprocess Engineering | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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