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Cyclosporine absorption profiles in pediatric kidney and liver transplant patients

dc.contributor.authorEttenger, Roberten_US
dc.contributor.authorSoergel, Marianneen_US
dc.contributor.authorHoyer, Peter F.en_US
dc.contributor.authorKovarik, John M.en_US
dc.contributor.authorPunch, Jeffrey D.en_US
dc.date.accessioned2006-09-11T19:25:53Z
dc.date.available2006-09-11T19:25:53Z
dc.date.issued2003-12en_US
dc.identifier.citationKovarik, J. M.; Hoyer, Peter F.; Ettenger, Robert; Punch, Jeffrey; Soergel, Marianne; (2003). "Cyclosporine absorption profiles in pediatric kidney and liver transplant patients." Pediatric Nephrology 18(12): 1275-1279. <http://hdl.handle.net/2027.42/47821>en_US
dc.identifier.issn1432-198Xen_US
dc.identifier.issn0931-041Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47821
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14577021&dopt=citationen_US
dc.description.abstractCyclosporine absorption profiling uses either the area under the concentration curve in the first 4 h post dose, AUC(0–4), or the concentration 2 h post dose (C2) to optimize immunosuppression in adult kidney and liver transplantation. We characterized C2 versus AUC(0–4) relationships over time after transplant and across transplant indications in 56 pediatric transplant patients. There were 36 kidney transplant patients aged 9.7±3.9 years. Nineteen of these patients were studied in the de novo period on day 7 post transplant and 17 in the maintenance phase more than 1 year post transplant. In addition, 20 liver transplant patients aged 8.9±4.2 years were studied in the maintenance phase. All patients had five blood samples collected over the 12-h dose interval that were analyzed by validated assay methods at a central laboratory. Pediatric C2 values were 1,463±658 ng/ml for de novo kidney, 954±322 ng/ml for maintenance kidney, and 619±339 ng/ml for maintenance liver transplant patients. C2 was a strong predictor of AUC(0–4) in all three pediatric groups, with coefficients of determination ( r 2 ) ranging from 0.861 to 0.936. Although data were limited from the de novo period, the C2 versus AUC(0–4) regression was consistent over time after transplant and between transplant indications, with a regression slope of 2.50 in de novo kidney, 2.54 in maintenance kidney, and 2.76 in maintenance liver transplant recipients. These slopes were also comparable to that in adult maintenance kidney transplant patients (2.60). In conclusion, C2 versus AUC(0–4) relationships demonstrated consistency over time (de novo vs. maintenance phase), between transplant indications (kidney vs. liver), and across age groups (pediatric vs. adult patients). Average C2 values achieved with current pediatric cyclosporine dosing practices cluster around the target C2 ranges recommended for adults.en_US
dc.format.extent149321 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; IPNAen_US
dc.subject.otherMedicineen_US
dc.subject.otherKidney Transplantationen_US
dc.subject.otherTherapeutic Drug Monitoringen_US
dc.subject.otherCyclosporineen_US
dc.subject.otherLiver Transplantationen_US
dc.subject.otherImmunosuppressionen_US
dc.titleCyclosporine absorption profiles in pediatric kidney and liver transplant patientsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arbor, MI 48109–0331, USAen_US
dc.contributor.affiliationotherNovartis Pharma AG, Building WSJ 27.4093, 4002 Basel, Switzerlanden_US
dc.contributor.affiliationotherDivision of Pediatric Nephrology, Mattel Children’s Hospital at UCLA, Los Angeles, CA 90095–1752, USAen_US
dc.contributor.affiliationotherNovartis Pharma AG, Building WSJ 27.4093, 4002 Basel, Switzerlanden_US
dc.contributor.affiliationotherDepartment of Pediatric Nephrology, Universitätsklinik Essen, 45122 Essen, Germanyen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid14577021en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47821/1/467_2003_Article_1260.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00467-003-1260-8en_US
dc.identifier.sourcePediatric Nephrologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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