Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome
Barletta, Gina-Marie; Bunchman, Timothy E.; Flynn, Joseph T.; Kershaw, David B.; Smoyer, William E.
2003-08
Citation
Barletta, Gina-Marie; Smoyer, William E.; Bunchman, Timothy E.; Flynn, Joseph T.; Kershaw, David B.; (2003). "Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome." Pediatric Nephrology 18(8): 833-837. <http://hdl.handle.net/2027.42/47822>
Abstract
Cyclosporin (Cs-A) is an effective treatment for difficult cases of nephrotic syndrome (NS), but its use can be complicated by renal toxicity and a high incidence of relapses after withdrawal. We reviewed the charts of 10 Cs-A-dependent patients and 4 patients with steroid-dependent nephrotic syndrome (SDNS) not previously treated with Cs-A therapy. All patients had persistent NS, even after prior treatment with oral cyclophosphamide. Of 10 patients treated with Cs-A, 4 had surveillance renal biopsies consistent with Cs-A toxicity, and 8 of 10 had interstitial fibrosis prior to mycophenolate mofetil (MMF). Patients were treated with MMF, at 1,200 mg/m 2 per day, in an attempt to allow weaning of Cs-A and/or steroid therapy, and reduce the frequency of relapses. Overall, a significant decrease in frequency of relapses was noted after initiation of MMF therapy. In addition, 5 patients were weaned off Cs-A by 1–2 years of follow-up. One patient was weaned off Cs-A and MMF, and remained in complete remission. However, the subgroup of patients with frequently relapsing SDNS not treated with Cs-A appeared to have a reduction in the number of relapses while on MMF that did not reach statistical significance. Two patients with intractable steroid-resistant NS continued to relapse repeatedly on MMF and Cs-A therapy. We conclude that in this small, single-center, uncontrolled experience, MMF therapy in patients with Cs-A-dependent NS appears to be effective in reducing Cs-A exposure. In addition, MMF appears to significantly decrease the frequency of relapses in this patient population. Further controlled studies are warranted to better define the potential efficacy and side effects of long-term MMF therapy in this setting.Publisher
Springer-Verlag; IPNA
ISSN
1432-198X 0931-041X
Other DOIs
PMID
12774223
Types
Article
URI
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12774223&dopt=citationMetadata
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