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dc.contributor.authorPerkin, Ronalden_US
dc.contributor.authorMcKenney, Daniel W.en_US
dc.contributor.authorReade, Erin Parrishen_US
dc.contributor.authorWhaley, Craigen_US
dc.contributor.authorLee, Danielen_US
dc.contributor.authorLin, Jen-Jaren_US
dc.date.accessioned2006-09-11T19:26:10Z
dc.date.available2006-09-11T19:26:10Z
dc.date.issued2004-09en_US
dc.identifier.citationReade, Erin Parrish; Whaley, Craig; Lin, Jen-Jar; McKenney, Daniel W.; Lee, Daniel; Perkin, Ronald; (2004). "Hypopnea in pediatric patients with obesity hypertension." Pediatric Nephrology 19(9): 1014-1020. <http://hdl.handle.net/2027.42/47825>en_US
dc.identifier.issn1432-198Xen_US
dc.identifier.issn0931-041Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47825
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15179571&dopt=citationen_US
dc.description.abstractObesity is associated with the development of hypertension but it is still not clear why hypertension is not observed in all obese patients. Obesity is a risk factor for the development of obstructive sleep apnea syndrome (OSAS) in children. OSAS has been linked to the development of hypertension in adults and children. The purpose of this study was to test the hypothesis that OSAS is one of the reasons that some obese children are hypertensive and some are not. The overnight polysomnography records of 90 patients (aged 4.2–18.8 years) were reviewed. BMI score [body mass index (BMI)/95th percentile BMI for age, sex, and race] was used to express the degree of obesity. The severity of systolic hypertension and diastolic hypertension were expressed as SBP score (systolic BP/the 95th percentile systolic BP for age, sex, and height) and DBP score (diastolic BP/the 95th percentile diastolic BP for age, sex, and height), respectively. OSAS was defined as more than one episodes of apnea per hour (AI) or an O 2 saturation associated with obstructive apnea of less than 90%. There were 56 obese patients; 42 were hypertensive and 40 patients were diagnosed with OSAS. The incidence of hypertension (68% vs. 30%) and obesity (75% vs. 52%) was higher in OSAS patients than those without OSAS. Compared with the non-obese patients, obese patients had a higher incidence of hypertension or OSAS, a higher BMI score , SBP score , DBP score , AI, hypopnea index (HI), and apnea-hypopnea index (AHI). In obese patients, both SBP score and DBP score correlated positively with BMI score , arousal index, and HI. DBP score also correlated positively with AHI. Multiple regression analysis showed that HI and BMI score were significant independent predictors of SBP score or DBP score . Obese and hypertensive patients had a higher HI, AHI, and incidence of OSAS (64% vs. 29%) than the obese and normotensive patients. In conclusion, HI had a significant correlation with the degree of hypertension in obese patients, which could not be attributed to the degree of obesity. These findings are consistent with the hypothesis that OSAS is one of the reasons why some obese children are hypertensive and some are not.en_US
dc.format.extent166366 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; IPNAen_US
dc.subject.otherHypertensionen_US
dc.subject.otherHypopneaen_US
dc.subject.otherSleep Apneaen_US
dc.subject.otherObesityen_US
dc.subject.otherMedicineen_US
dc.titleHypopnea in pediatric patients with obesity hypertensionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA; Department of Pediatric Nephrology, University of Michigan, Mott Children’s Hospital, F6865/0297, 1505 Simpson Road East, Ann Arbor, MI 48109–0297, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USAen_US
dc.contributor.affiliationotherEast Carolina Neurology, Greenville, North Carolina, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Kosair Charities Pediatric Center, University of Kentucky at Louisville, Kentucky, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15179571en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47825/1/467_2004_Article_1513.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00467-004-1513-1en_US
dc.identifier.sourcePediatric Nephrologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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