Glucose transporters in diabetic nephropathy

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dc.contributor.author Brosius, Frank C. en_US
dc.contributor.author Heilig, Charles W. en_US
dc.date.accessioned 2006-09-11T19:26:14Z
dc.date.available 2006-09-11T19:26:14Z
dc.date.issued 2005-04 en_US
dc.identifier.citation Brosius, Frank C.; Heilig, Charles W.; (2005). "Glucose transporters in diabetic nephropathy." Pediatric Nephrology 20(4): 447-451. <http://hdl.handle.net/2027.42/47826> en_US
dc.identifier.issn 0931-041X en_US
dc.identifier.issn 1432-198X en_US
dc.identifier.uri http://hdl.handle.net/2027.42/47826
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15717166&dopt=citation en_US
dc.description.abstract Changes in glucose transporter expression in glomerular cells occur early in diabetes. These changes, especially the GLUT1 increase in mesangial cells, appear to play a pathogenic role in the development of ECM expansion and perhaps other features of diabetic nephropathy. In addition, it appears that at least some diabetic patients may be predisposed to nephropathy because of polymorphisms in their GLUT1 genes. GLUT1 overexpression leads to increased glucose metabolic flux which in turn triggers the polyol pathway and activation of PKCα and Β1. Activation of these PKC isoforms can lead directly to AP-1 induced increases in fibronectin expression and ECM accumulation. Other, more novel effects of GLUT1 on cellular hypertrophy and injury could also promote changes of diabetic nephropathy. Strategies to prevent GLUT1 overexpression could ameliorate or prevent the progression of diabetic nephropathy. en_US
dc.format.extent 166760 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag; IPNA en_US
dc.subject.other Mouse en_US
dc.subject.other Type 1 Diabetes Mellitus en_US
dc.subject.other Diabetic Nephropathy en_US
dc.subject.other Podocyte en_US
dc.subject.other Rat en_US
dc.subject.other Reactive Oxygen Species en_US
dc.title Glucose transporters in diabetic nephropathy en_US
dc.type Review en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbsecondlevel Pediatrics en_US
dc.subject.hlbsecondlevel Internal Medicine and Specialties en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Departments of Internal Medicine and Physiology, University of Michigan, 1150 W. Medical Center Dr., 1560 MSRB2, Ann Arbor, MI 48109-0676, USA en_US
dc.contributor.affiliationother Departments of Medicine and Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 15717166 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/47826/1/467_2004_Article_1748.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/s00467-004-1748-x en_US
dc.identifier.source Pediatric Nephrology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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