Predicted reciprocal serum creatinine at age 10 years as a measure of renal function in children with nephropathic cystinosis treated with oral cysteamine
dc.contributor.author | Reed, George F. | en_US |
dc.contributor.author | Schulman, Joseph D. | en_US |
dc.contributor.author | Gahl, William A. | en_US |
dc.contributor.author | Thoene, Jess G. | en_US |
dc.contributor.author | Schneider, Jerry A. | en_US |
dc.date.accessioned | 2006-09-11T19:26:22Z | |
dc.date.available | 2006-09-11T19:26:22Z | |
dc.date.issued | 1990-03 | en_US |
dc.identifier.citation | Gahl, William A.; Schneider, Jerry A.; Schulman, Joseph D.; Thoene, Jess G.; Reed, George F.; (1990). "Predicted reciprocal serum creatinine at age 10 years as a measure of renal function in children with nephropathic cystinosis treated with oral cysteamine." Pediatric Nephrology 4(2): 129-135. <http://hdl.handle.net/2027.42/47828> | en_US |
dc.identifier.issn | 1432-198X | en_US |
dc.identifier.issn | 0931-041X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47828 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2397178&dopt=citation | en_US |
dc.description.abstract | The predicted reciprocal creatinine at age 10 years (PRC 10 ), a parameter of renal function based upon the linear relationship between reciprocal serum creatinine and age, incorporates age, serum creatinine, and rate of renal deterioration into a single term. PRC 10 measurements were employed to assess renal function in children with nephropathic cystinosis treated with oral cysteamine, a cystine-depleting agent. In 71 children receiving oral cysteamine for at least 1 year, PRC 10 decreased linearly with initial serum creatinine concentration. This indicated that, although established renal damage in cystinosis was irreversible, early intervention with cysteamine therapy could favorably alter the rate of glomerular deterioration. In other analyses, mean PRC 10 was shown to increase with duration of cysteamine therapy and extent of leukocyte cystine depletion. The predicted reciprocal creatinine value at a certain age can be useful in analyzing the effects of therapeutic intervention in a disease with a relatively uniform rate of renal deterioration. | en_US |
dc.format.extent | 732473 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; IPNA | en_US |
dc.subject.other | Creatinine Clearance | en_US |
dc.subject.other | Nephropathic Cystinosis | en_US |
dc.subject.other | Pediatrics | en_US |
dc.subject.other | Renal Function | en_US |
dc.subject.other | Reciprocal Serum Creatinine | en_US |
dc.subject.other | Cysteamine | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | Predicted reciprocal serum creatinine at age 10 years as a measure of renal function in children with nephropathic cystinosis treated with oral cysteamine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of California, San Diego, 92093, La Jolla, CA, USA | en_US |
dc.contributor.affiliationother | Biometry Branch, National Institute of Child Health and Human Development, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Human Genetics Branch, National Institute of Child Health and Human Development, Building 10, Room 8C-429, National Institutes of Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Genetics and IVF Institute and Fairfax Hospital, 22031, Fairfax, VA, USA; Medical College of Virginia, 23298, Richmond, VA, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2397178 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47828/1/467_2004_Article_BF00858823.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00858823 | en_US |
dc.identifier.source | Pediatric Nephrology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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