Insulin and glucagon secretion in essential fatty acid deficient rats
dc.contributor.author | Hurley, Mary C. | en_US |
dc.contributor.author | Akpan, Jones O. | en_US |
dc.contributor.author | Lands, William E. M. | en_US |
dc.date.accessioned | 2006-09-11T19:36:53Z | |
dc.date.available | 2006-09-11T19:36:53Z | |
dc.date.issued | 1981-04 | en_US |
dc.identifier.citation | Akpan, Jones O.; Hurley, Mary C.; Lands, William E. M.; (1981). "Insulin and glucagon secretion in essential fatty acid deficient rats." Acta Diabetologica Latina 18(2): 147-156. <http://hdl.handle.net/2027.42/47974> | en_US |
dc.identifier.issn | 0940-5429 | en_US |
dc.identifier.issn | 1432-5233 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47974 | |
dc.description.abstract | Insulin and glucagon secretion in response to common secretagogues were ascertained in the perfused pancreas isolated from essential fatty acid deficient rats. The pattern of insulin secretory response to glucose (16.7 mmol/l) by isolated rat pancreas perfused for 30 min was biphasic in EFA-deficient and control rat pancreas. The amplitude of glucose-stimulated acute secretion (phase I) was significantly greater (p<0.01) in magnitude and amplitude in EFA-deficient rats than in the control rats. There was no significant difference in the second phase of glucosestimulated insulin secretion in the two groups. Glucagon secretion in EFA-deficient and control rats was inhibited by glucose (16.7 mmol/l). Glucagon secretion induced by L-arginine (10 mmol/l) was not significantly different in EFA-deficient and in control rat pancreata (p>0.05). However, arginine (10 mmol/l)-stimulated insulin release was significantly higher in EFA-deficient than in control rats. Growth hormone (100 nmol/l)-induced glucagon and insulin secretion was variable in the two groups but significantly higher than basal secretion. The level of L-leucine (10 mmol/l)-stimulated glucagon and insulin secretion in EFA-deficient rats was minimal but significant. Our results show that isolated pancreata of rats devoid of precursors for endogenous prostaglandin synthesis secreted insulin and glucagon in response to common secretagogues. On the basis of our data, it is concluded that endogenous prostaglandins are probably not obligatory for normal secretory functions of islets of Langerhans. | en_US |
dc.format.extent | 662915 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Casa Editrice | en_US |
dc.subject.other | Diabetes | en_US |
dc.subject.other | Metabolic Diseases | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Prostaglandins | en_US |
dc.subject.other | Insulin and Glucagon Secretion | en_US |
dc.subject.other | Essential Fatty Acid Deficient Rats | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | Insulin and glucagon secretion in essential fatty acid deficient rats | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Division of Endocrinology and Metabolism and The Metabolism Research Unit Department of Biological Chemistry, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Division of Endocrinology and Metabolism and The Metabolism Research Unit Department of Biological Chemistry, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | Department of Internal Medicine Division of Endocrinology and Metabolism and The Metabolism Research Unit Department of Biological Chemistry, University of Michigan, Ann Arbor; Department of Clinical Pharmacology, University of Ilorin, Ilorin Kwara State, Nigeria | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47974/1/592_2005_Article_BF02099000.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02099000 | en_US |
dc.identifier.source | Acta Diabetologica Latina | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.