Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone
dc.contributor.author | Goldstein, Steven A. | en_US |
dc.contributor.author | Goulet, Robert W. | en_US |
dc.contributor.author | McCubbrey, Doris | en_US |
dc.date.accessioned | 2006-09-11T19:39:00Z | |
dc.date.available | 2006-09-11T19:39:00Z | |
dc.date.issued | 1993-02 | en_US |
dc.identifier.citation | Goldstein, Steven A.; Goulet, Robert; McCubbrey, Doris; (1993). "Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone." Calcified Tissue International 53(1): S127-S133. <http://hdl.handle.net/2027.42/48005> | en_US |
dc.identifier.issn | 1432-0827 | en_US |
dc.identifier.issn | 0171-967X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48005 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8275366&dopt=citation | en_US |
dc.description.abstract | The mechanical properties of trabecular bone have been shown to vary significantly with age, anatomic location, and metabolic condition. Efforts towards predicting its behavior have been extensive, and significant relationship between measures of density and mechanical integrity have been reported. Unfortunately, the significant heterogeneity in trabecular bone anisotropy contributes to significant unexplained variance in its strength and modulus when predicted using scalar measures of mass or density. As a result, numerous investigators have attempted to include measures of architecture in an effort to more rigorously investigate potential physiologic optimization strategies, as well as account for the increased fragility associated with advancing age. In our laboratories we have utilized a unique three-dimensional, microcomputed tomography system to measure trabecular plate thickness, trabecular plate separation, trabecular plate number, surface to volume ratio, bone volume fraction, anisotropy, and connectivity in isolated specimens of trabecular bone. The results of these studies demonstrate that in normal bone, more than 80% of the variance in its mechanical behavior can be explained by measures of density and orientation. The independent measures of connectivity and trabecular plate number were found to be significantly correlated with bone volume fraction, suggesting a potential strategy in the formation of trabecular bone. It might be hypothesized, however, that the relationship between bone volume fraction and connectivity may be substantially altered under conditions associated with aging, fragility, or metabolic bone disease. This hypothesis would be consistent with the histologic, evidence of reduced connectivity in osteopenic patients. | en_US |
dc.format.extent | 810482 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Trabecular Bone | en_US |
dc.subject.other | Orthopedics | en_US |
dc.subject.other | Density | en_US |
dc.subject.other | Mechanical Integrity | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Endocrinology | en_US |
dc.title | Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8275366 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48005/1/223_2005_Article_BF01673421.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01673421 | en_US |
dc.identifier.source | Calcified Tissue International | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.