Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone

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dc.contributor.author Goldstein, Steven A. en_US
dc.contributor.author Goulet, Robert W. en_US
dc.contributor.author McCubbrey, Doris en_US
dc.date.accessioned 2006-09-11T19:39:00Z
dc.date.available 2006-09-11T19:39:00Z
dc.date.issued 1993-02 en_US
dc.identifier.citation Goldstein, Steven A.; Goulet, Robert; McCubbrey, Doris; (1993). "Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone." Calcified Tissue International 53(1): S127-S133. <http://hdl.handle.net/2027.42/48005> en_US
dc.identifier.issn 1432-0827 en_US
dc.identifier.issn 0171-967X en_US
dc.identifier.uri http://hdl.handle.net/2027.42/48005
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8275366&dopt=citation en_US
dc.description.abstract The mechanical properties of trabecular bone have been shown to vary significantly with age, anatomic location, and metabolic condition. Efforts towards predicting its behavior have been extensive, and significant relationship between measures of density and mechanical integrity have been reported. Unfortunately, the significant heterogeneity in trabecular bone anisotropy contributes to significant unexplained variance in its strength and modulus when predicted using scalar measures of mass or density. As a result, numerous investigators have attempted to include measures of architecture in an effort to more rigorously investigate potential physiologic optimization strategies, as well as account for the increased fragility associated with advancing age. In our laboratories we have utilized a unique three-dimensional, microcomputed tomography system to measure trabecular plate thickness, trabecular plate separation, trabecular plate number, surface to volume ratio, bone volume fraction, anisotropy, and connectivity in isolated specimens of trabecular bone. The results of these studies demonstrate that in normal bone, more than 80% of the variance in its mechanical behavior can be explained by measures of density and orientation. The independent measures of connectivity and trabecular plate number were found to be significantly correlated with bone volume fraction, suggesting a potential strategy in the formation of trabecular bone. It might be hypothesized, however, that the relationship between bone volume fraction and connectivity may be substantially altered under conditions associated with aging, fragility, or metabolic bone disease. This hypothesis would be consistent with the histologic, evidence of reduced connectivity in osteopenic patients. en_US
dc.format.extent 810482 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag; Springer-Verlag New York Inc. en_US
dc.subject.other Biochemistry, General en_US
dc.subject.other Trabecular Bone en_US
dc.subject.other Orthopedics en_US
dc.subject.other Density en_US
dc.subject.other Mechanical Integrity en_US
dc.subject.other Life Sciences en_US
dc.subject.other Cell Biology en_US
dc.subject.other Endocrinology en_US
dc.title Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone en_US
dc.type Session VI en_US
dc.subject.hlbsecondlevel Dentistry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Orthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 8275366 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/48005/1/223_2005_Article_BF01673421.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF01673421 en_US
dc.identifier.source Calcified Tissue International en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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