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dc.contributor.authorGoldstein, Steven A.en_US
dc.contributor.authorGoulet, Robert W.en_US
dc.contributor.authorMcCubbrey, Dorisen_US
dc.date.accessioned2006-09-11T19:39:00Z
dc.date.available2006-09-11T19:39:00Z
dc.date.issued1993-02en_US
dc.identifier.citationGoldstein, Steven A.; Goulet, Robert; McCubbrey, Doris; (1993). "Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone." Calcified Tissue International 53(1): S127-S133. <http://hdl.handle.net/2027.42/48005>en_US
dc.identifier.issn1432-0827en_US
dc.identifier.issn0171-967Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48005
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8275366&dopt=citationen_US
dc.description.abstractThe mechanical properties of trabecular bone have been shown to vary significantly with age, anatomic location, and metabolic condition. Efforts towards predicting its behavior have been extensive, and significant relationship between measures of density and mechanical integrity have been reported. Unfortunately, the significant heterogeneity in trabecular bone anisotropy contributes to significant unexplained variance in its strength and modulus when predicted using scalar measures of mass or density. As a result, numerous investigators have attempted to include measures of architecture in an effort to more rigorously investigate potential physiologic optimization strategies, as well as account for the increased fragility associated with advancing age. In our laboratories we have utilized a unique three-dimensional, microcomputed tomography system to measure trabecular plate thickness, trabecular plate separation, trabecular plate number, surface to volume ratio, bone volume fraction, anisotropy, and connectivity in isolated specimens of trabecular bone. The results of these studies demonstrate that in normal bone, more than 80% of the variance in its mechanical behavior can be explained by measures of density and orientation. The independent measures of connectivity and trabecular plate number were found to be significantly correlated with bone volume fraction, suggesting a potential strategy in the formation of trabecular bone. It might be hypothesized, however, that the relationship between bone volume fraction and connectivity may be substantially altered under conditions associated with aging, fragility, or metabolic bone disease. This hypothesis would be consistent with the histologic, evidence of reduced connectivity in osteopenic patients.en_US
dc.format.extent810482 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer-Verlag New York Inc.en_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherTrabecular Boneen_US
dc.subject.otherOrthopedicsen_US
dc.subject.otherDensityen_US
dc.subject.otherMechanical Integrityen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherCell Biologyen_US
dc.subject.otherEndocrinologyen_US
dc.titleMeasurement and significance of three-dimensional architecture to the mechanical integrity of trabecular boneen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumOrthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumOrthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumOrthopaedic Research Laboratories, Section of Orthopaedic Surgery, University of Michigan, 48109-0486, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8275366en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48005/1/223_2005_Article_BF01673421.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF01673421en_US
dc.identifier.sourceCalcified Tissue Internationalen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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