Three quantitative ultrasound parameters reflect bone structure

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dc.contributor.author Jergas, M. en_US
dc.contributor.author Genant, H. K. en_US
dc.contributor.author Goldstein, Steven A. en_US
dc.contributor.author Wu, C. Y. en_US
dc.contributor.author Gluer, C. C. en_US
dc.date.accessioned 2006-09-11T19:39:04Z
dc.date.available 2006-09-11T19:39:04Z
dc.date.issued 1994-07 en_US
dc.identifier.citation Gluer, C. C.; Wu, C. Y.; Jergas, M.; Goldstein, S. A.; Genant, H. K.; (1994). "Three quantitative ultrasound parameters reflect bone structure." Calcified Tissue International 55(1): 46-52. <http://hdl.handle.net/2027.42/48006> en_US
dc.identifier.issn 1432-0827 en_US
dc.identifier.issn 0171-967X en_US
dc.identifier.uri http://hdl.handle.net/2027.42/48006
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7922789&dopt=citation en_US
dc.description.abstract We investigated whether quantitative ultrasound (QUS) parameters are associated with bone structure. In an in vitro study on 20 cubes of trabecular bone, we measured broadband ultrasound attenuation (BUA) and two newly defined parameters—ultrasound velocity through bone (UVB) and ultrasound attenuation in bone (UAB). Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA) and bone structure was assessed by microcomputed tomography (μCT) with approximately 80 μm spatial resolution. We found all three QUS parameters to be significantly associated with bone structure independently of BMD. UVB was largely influenced by trabecular separation, UAB by connectivity, and BUA by a combination of both. For a one standard deviation (SD) increase in UVB, a decrease in trabecular separation of 1.2 SD was required compared with a 1.4 SD increase in BMD for the same effect. A 1.0 SD increase in UAB required a reduction in connectivity of 1.4 SD. Multivariate models of QUS versus BMD combined with bone structure parameters showed squared correlation coefficients of r 2 =0.70–0.85 for UVB, r 2 =0.27–0.56 for UAB, and r 2 =0.30–0.68 for BUA compared with r 2 =0.18–0.58 for UVB, r 2 <0.26 for UAB and r 2 <0.13 for BUA for models including BMD alone. QUS thus reflects bone structure, and a combined analysis of QUS and BMD will allow for a more comprehensive assessment of skeletal status than either method alone. en_US
dc.format.extent 984078 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag en_US
dc.subject.other Orthopedics en_US
dc.subject.other Ultrasound en_US
dc.subject.other Osteoporosis en_US
dc.subject.other Endocrinology en_US
dc.subject.other Bone Densitometry en_US
dc.subject.other Bone Structure en_US
dc.subject.other Cell Biology en_US
dc.subject.other Life Sciences en_US
dc.subject.other Biochemistry, General en_US
dc.title Three quantitative ultrasound parameters reflect bone structure en_US
dc.type Laboratory Investigations en_US
dc.subject.hlbsecondlevel Dentistry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Orthopaedic Research Laboratories at the University of Michigan, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationother Osteoporosis Research Group, Department of Radiology, University of California, Box 0628, 94143, San Francisco, California, USA en_US
dc.contributor.affiliationother Osteoporosis Research Group, Department of Radiology, University of California, Box 0628, 94143, San Francisco, California, USA en_US
dc.contributor.affiliationother Osteoporosis Research Group, Department of Radiology, University of California, Box 0628, 94143, San Francisco, California, USA en_US
dc.contributor.affiliationother Osteoporosis Research Group, Department of Radiology, University of California, Box 0628, 94143, San Francisco, California, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 7922789 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/48006/1/223_2004_Article_BF00310168.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF00310168 en_US
dc.identifier.source Calcified Tissue International en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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