Structural simplicity of the Zonula Occludens in the electrolyte secreting epithelium of the avian salt gland
dc.contributor.author | Riddle, Clara V. | en_US |
dc.contributor.author | Ernst, Stephen A. | en_US |
dc.date.accessioned | 2006-09-11T19:40:35Z | |
dc.date.available | 2006-09-11T19:40:35Z | |
dc.date.issued | 1979-03 | en_US |
dc.identifier.citation | Riddle, Clara V.; Ernst, Stephen A.; (1979). "Structural simplicity of the Zonula Occludens in the electrolyte secreting epithelium of the avian salt gland." The Journal of Membrane Biology 45 (1-2): 21-35. <http://hdl.handle.net/2027.42/48028> | en_US |
dc.identifier.issn | 0022-2631 | en_US |
dc.identifier.issn | 1432-1424 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48028 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=448725&dopt=citation | en_US |
dc.description.abstract | The structure of the zonula occludens in the secretory epithelium of the salt gland of the domestic duck was determined by thin section and freeze-fracture electron microscopy. These glands secrete an effluent with a NaCl concentration four times that of plasma, and thus maintain a steep ionic gradient across their secretory epithelium. Freezefracture replicas from salt stressed ducks demonstrate that the zonula occludens is surprisingly shallow in depth (20–25 nm) and generally consists of two parallel junctional strands which are juxaposed along their entire length. In addition to the simplicity of the junction separating mucosal and serosal compartments, the ratio of junctional length to apical surface area is large since luminal surfaces of secretory cells are narrow and intermesh with one another. The zonula occludens in nonsecreting fresh water-adapted birds is similar to the salt stressed group except that two sets of double strand junctions are seen in addition to junctions consisting of a single set. Based on previous ultrastructural, cytochemical and physiological studies in salt glands and in other epithelia, a model for salt secretion was suggested in which intercellular space Na + , generated by basolateral ouabain-sensitive Na + pumps, reaches the lumen via a paracellular route (Ernst & Mills, 1977, J. Cell Biol. 75 :74). The simplicity of the morphological appearance of the zonula occludens in the salt gland, which resembles that described for several epithelia known to be leaky to ions, is consistent with this hypothesis. | en_US |
dc.format.extent | 4105124 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Human Physiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.title | Structural simplicity of the Zonula Occludens in the electrolyte secreting epithelium of the avian salt gland | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy, Temple University School of Medicine, 19140, Philadelphia, Pennsylvania; Department of Anatomy, University of Michigan Medical School, Medical Science II, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Anatomy, Temple University School of Medicine, 19140, Philadelphia, Pennsylvania; Department of Ophthalmology, University of Oregon Health Sciences Center, 97201, Portland, Oregon | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 448725 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48028/1/232_2005_Article_BF01869292.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01869292 | en_US |
dc.identifier.source | The Journal of Membrane Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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