Optimal design of feedback control by inhibition

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dc.contributor.author Savageau, Michael A. en_US
dc.date.accessioned 2006-09-11T19:42:20Z
dc.date.available 2006-09-11T19:42:20Z
dc.date.issued 1975-09 en_US
dc.identifier.citation Savageau, Michael A.; (1975). "Optimal design of feedback control by inhibition." Journal of Molecular Evolution 5(3): 199-222. <http://hdl.handle.net/2027.42/48053> en_US
dc.identifier.issn 1432-1432 en_US
dc.identifier.issn 0022-2844 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/48053
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1159800&dopt=citation en_US
dc.description.abstract The local stability of unbranched biosynthetic pathways is examined by mathematical analysis and computer simulation using a novel nonlinear formalism that appears to accurately describe biochemical systems. Four factors affecting the stability are examined: strength of feedback inhibition, equalization of the values among the corresponding kinetic parameters for the reactions of the pathway, pathway length, and alternative patterns of feedback interaction. The strength of inhibition and the pattern of feedback interactions are important determinants of steady-state behavior. The simple pattern of end-product inhibition in unbranched pathways may have evolved because it optimizes the steady-state behavior and is temporally most responsive to change. Stability in these simple systems is achieved by shortening pathway length either physically or, in the case of necessarily long pathways, kinetically by a wide divergence in the values of the corresponding kinetic parameters for the reactions of the pathway. These conclusions are discussed in the light of available experimental evidence. en_US
dc.format.extent 1008085 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag en_US
dc.subject.other Life Sciences en_US
dc.subject.other Cell Biology en_US
dc.subject.other Control Patterns en_US
dc.subject.other Biosynthetic Pathways en_US
dc.subject.other Microbiology en_US
dc.subject.other Plant Sciences en_US
dc.subject.other Natural Selection en_US
dc.title Optimal design of feedback control by inhibition en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Microbiology, The University of Michigan Medical School, 6643 Medical Science Building II, 48104, Ann Arbor, Mich., USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 1159800 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/48053/1/239_2005_Article_BF01741242.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF01741242 en_US
dc.identifier.source Journal of Molecular Evolution en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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