Optimal design of feedback control by inhibition
dc.contributor.author | Savageau, Michael A. | en_US |
dc.date.accessioned | 2006-09-11T19:42:20Z | |
dc.date.available | 2006-09-11T19:42:20Z | |
dc.date.issued | 1975-09 | en_US |
dc.identifier.citation | Savageau, Michael A.; (1975). "Optimal design of feedback control by inhibition." Journal of Molecular Evolution 5(3): 199-222. <http://hdl.handle.net/2027.42/48053> | en_US |
dc.identifier.issn | 1432-1432 | en_US |
dc.identifier.issn | 0022-2844 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48053 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1159800&dopt=citation | en_US |
dc.description.abstract | The local stability of unbranched biosynthetic pathways is examined by mathematical analysis and computer simulation using a novel nonlinear formalism that appears to accurately describe biochemical systems. Four factors affecting the stability are examined: strength of feedback inhibition, equalization of the values among the corresponding kinetic parameters for the reactions of the pathway, pathway length, and alternative patterns of feedback interaction. The strength of inhibition and the pattern of feedback interactions are important determinants of steady-state behavior. The simple pattern of end-product inhibition in unbranched pathways may have evolved because it optimizes the steady-state behavior and is temporally most responsive to change. Stability in these simple systems is achieved by shortening pathway length either physically or, in the case of necessarily long pathways, kinetically by a wide divergence in the values of the corresponding kinetic parameters for the reactions of the pathway. These conclusions are discussed in the light of available experimental evidence. | en_US |
dc.format.extent | 1008085 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Control Patterns | en_US |
dc.subject.other | Biosynthetic Pathways | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.subject.other | Natural Selection | en_US |
dc.title | Optimal design of feedback control by inhibition | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, The University of Michigan Medical School, 6643 Medical Science Building II, 48104, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1159800 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48053/1/239_2005_Article_BF01741242.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01741242 | en_US |
dc.identifier.source | Journal of Molecular Evolution | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.