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Pulmonary vascular changes associated with hypoplastic left ventricle syndrome

dc.contributor.authorNeumann, M. Paulaen_US
dc.contributor.authorDick, Macdonald IIen_US
dc.contributor.authorHeidelberger, Kathleen P.en_US
dc.contributor.authorRosenthal, Amnonen_US
dc.date.accessioned2006-09-11T19:45:55Z
dc.date.available2006-09-11T19:45:55Z
dc.date.issued1980-12en_US
dc.identifier.citationNeumann, M. Paula; Heidelberger, Kathleen P.; Dick, Macdonald; Rosenthal, Amnon; (1980). "Pulmonary vascular changes associated with hypoplastic left ventricle syndrome." Pediatric Cardiology 1(4): 301-306. <http://hdl.handle.net/2027.42/48096>en_US
dc.identifier.issn1432-1971en_US
dc.identifier.issn0172-0643en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48096
dc.description.abstractThe lungs of ten newborn infants who died of hypoplastic left ventricle syndrome were studied by a morphometric technique that (1) determined the percentage wall thickness of injected pulmonary arteries, (2) determined the ratio between the number of alveoli per high-power field and the number of corresponding arteries, and (3) examined in detail the extension of medial smooth muscle to the vessels at the periphery of the acinus. The findings in the lung were related to the gross cardiac morphological changes and to echocardiographic and hemodynamic findings. The echocardiograms of eight neonates demonstrated small left ventricles. The aortic root was hypoplastic in seven and the left atrium was small in three of the eight. Pulmonary artery hypertension and elevation of the left atrial pressure were present in all infants in whom measurements were obtained. The mean percentage wall thickness of all vessels was greater in afflicted infants than in normal age-matched control subjects. There was a normal ratio between the number of alveoli per high-power field and the number of corresponding arteries, and all infants had extension of muscle to the peripheral vessels at the alveolar duct and alveolar wall levels. The pulmonary vascular abnormalities observed in the neonate with hypoplastic left ventricle syndrome may represent persistence of fetal vascular abnormalities associated with the abnormal fetal circulatory hemodynamics resulting from the malformation. These abnormalities may influence the success of surgery proposed for hypoplastic left ventricle syndrome.en_US
dc.format.extent429148 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherVascular Surgeryen_US
dc.subject.otherCardiac Surgeryen_US
dc.subject.otherAbnormal Pulmonary Vasculatureen_US
dc.subject.otherHypoplastic Left Ventricleen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherCardiologyen_US
dc.titlePulmonary vascular changes associated with hypoplastic left ventricle syndromeen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, 1335 East Catherine Street, 48109, Ann Arbor, Michigan; Section of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, 1335 East Catherine Street, 48109, Ann Arbor, Michigan; Section of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, 1335 East Catherine Street, 48109, Ann Arbor, Michigan; Section of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical Center, 1335 East Catherine Street, 48109, Ann Arbor, Michigan; Section of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48096/1/246_2006_Article_BF02336435.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF02336435en_US
dc.identifier.sourcePediatric Cardiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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