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MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria

dc.contributor.authorRoubidoux, Marilyn A.en_US
dc.date.accessioned2006-09-11T19:49:18Z
dc.date.available2006-09-11T19:49:18Z
dc.date.issued1994-03en_US
dc.identifier.citationRoubidoux, M. A.; (1994). "MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria." Abdominal Imaging 19(2): 168-173. <http://hdl.handle.net/2027.42/48141>en_US
dc.identifier.issn0942-8925en_US
dc.identifier.issn1432-0509en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48141
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8199554&dopt=citationen_US
dc.description.abstractThe magnetic resonance (MR) findings in the liver, kidneys, and spleen in eight patients with paroxysmal nocturnal hemoglobinuria (PNH) were retrospectively reviewed to determine whether characteristic features could be demonstrated. Eight patients underwent abdominal MR examinations by gradient echo sequences (seven patients), spin-echo sequences (seven patients), and inversion recovery (one patient). Signal intensities of the kidneys, liver, and spleen were visually evaluated. Autopsy and liver biopsy correlation were available in one case each. Renal signal intensity was decreased in all eight patients by either gradient-echo or T2-weighted sequences and in the single inversion recovery sequence. Hepatic signal intensity was decreased in three of eight patients on spin- and gradient-echo images. Splenic signal intensity was decreased in three of eight patients on spin- and gradient-echo images, and in two of these was manifest as focal low signal spots (Gamna-Gandy bodies). While the signal intensity in the renal cortex is typically decreased in patients with PNH, signal intensities in the liver and spleen are variable. Low signal intensity in the kidneys is due to hemosiderin deposition resulting from intravascular hemolysis, whereas low signal intensity in the liver or spleen may be due to either transfusion siderosis, or as a consequence of hepatic or portal venous thrombosis.en_US
dc.format.extent2025517 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer-Verlag New York, Inc.en_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherHepatologyen_US
dc.subject.otherParoxysmal Nocturnal Hemoglobinuriaen_US
dc.subject.otherImaging / Radiologyen_US
dc.subject.otherGastroenterologyen_US
dc.subject.otherKidneys, MR Studiesen_US
dc.subject.otherSpleen, MR Studiesen_US
dc.subject.otherAnemiaen_US
dc.subject.otherLiver, MR Studiesen_US
dc.titleMR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuriaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelRadiologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Radiology, Duke University Medical Center, 27710, Durham, NC, USA; Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, TC2910, 48109-0326, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8199554en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48141/1/261_2004_Article_BF00203497.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00203497en_US
dc.identifier.sourceAbdominal Imagingen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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