MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria

Show simple item record Roubidoux, Marilyn A. en_US 2006-09-11T19:49:18Z 2006-09-11T19:49:18Z 1994-03 en_US
dc.identifier.citation Roubidoux, M. A.; (1994). "MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria." Abdominal Imaging 19(2): 168-173. <> en_US
dc.identifier.issn 0942-8925 en_US
dc.identifier.issn 1432-0509 en_US
dc.identifier.uri en_US
dc.description.abstract The magnetic resonance (MR) findings in the liver, kidneys, and spleen in eight patients with paroxysmal nocturnal hemoglobinuria (PNH) were retrospectively reviewed to determine whether characteristic features could be demonstrated. Eight patients underwent abdominal MR examinations by gradient echo sequences (seven patients), spin-echo sequences (seven patients), and inversion recovery (one patient). Signal intensities of the kidneys, liver, and spleen were visually evaluated. Autopsy and liver biopsy correlation were available in one case each. Renal signal intensity was decreased in all eight patients by either gradient-echo or T2-weighted sequences and in the single inversion recovery sequence. Hepatic signal intensity was decreased in three of eight patients on spin- and gradient-echo images. Splenic signal intensity was decreased in three of eight patients on spin- and gradient-echo images, and in two of these was manifest as focal low signal spots (Gamna-Gandy bodies). While the signal intensity in the renal cortex is typically decreased in patients with PNH, signal intensities in the liver and spleen are variable. Low signal intensity in the kidneys is due to hemosiderin deposition resulting from intravascular hemolysis, whereas low signal intensity in the liver or spleen may be due to either transfusion siderosis, or as a consequence of hepatic or portal venous thrombosis. en_US
dc.format.extent 2025517 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag; Springer-Verlag New York, Inc. en_US
dc.subject.other Medicine & Public Health en_US
dc.subject.other Hepatology en_US
dc.subject.other Paroxysmal Nocturnal Hemoglobinuria en_US
dc.subject.other Imaging / Radiology en_US
dc.subject.other Gastroenterology en_US
dc.subject.other Kidneys, MR Studies en_US
dc.subject.other Spleen, MR Studies en_US
dc.subject.other Anemia en_US
dc.subject.other Liver, MR Studies en_US
dc.title MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Radiology en_US
dc.subject.hlbsecondlevel Internal Medicine and Specialties en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Radiology, Duke University Medical Center, 27710, Durham, NC, USA; Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, TC2910, 48109-0326, Ann Arbor, MI, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 8199554 en_US
dc.description.bitstreamurl en_US
dc.identifier.doi en_US
dc.identifier.source Abdominal Imaging en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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