MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria
dc.contributor.author | Roubidoux, Marilyn A. | en_US |
dc.date.accessioned | 2006-09-11T19:49:18Z | |
dc.date.available | 2006-09-11T19:49:18Z | |
dc.date.issued | 1994-03 | en_US |
dc.identifier.citation | Roubidoux, M. A.; (1994). "MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria." Abdominal Imaging 19(2): 168-173. <http://hdl.handle.net/2027.42/48141> | en_US |
dc.identifier.issn | 0942-8925 | en_US |
dc.identifier.issn | 1432-0509 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48141 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8199554&dopt=citation | en_US |
dc.description.abstract | The magnetic resonance (MR) findings in the liver, kidneys, and spleen in eight patients with paroxysmal nocturnal hemoglobinuria (PNH) were retrospectively reviewed to determine whether characteristic features could be demonstrated. Eight patients underwent abdominal MR examinations by gradient echo sequences (seven patients), spin-echo sequences (seven patients), and inversion recovery (one patient). Signal intensities of the kidneys, liver, and spleen were visually evaluated. Autopsy and liver biopsy correlation were available in one case each. Renal signal intensity was decreased in all eight patients by either gradient-echo or T2-weighted sequences and in the single inversion recovery sequence. Hepatic signal intensity was decreased in three of eight patients on spin- and gradient-echo images. Splenic signal intensity was decreased in three of eight patients on spin- and gradient-echo images, and in two of these was manifest as focal low signal spots (Gamna-Gandy bodies). While the signal intensity in the renal cortex is typically decreased in patients with PNH, signal intensities in the liver and spleen are variable. Low signal intensity in the kidneys is due to hemosiderin deposition resulting from intravascular hemolysis, whereas low signal intensity in the liver or spleen may be due to either transfusion siderosis, or as a consequence of hepatic or portal venous thrombosis. | en_US |
dc.format.extent | 2025517 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York, Inc. | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Paroxysmal Nocturnal Hemoglobinuria | en_US |
dc.subject.other | Imaging / Radiology | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | Kidneys, MR Studies | en_US |
dc.subject.other | Spleen, MR Studies | en_US |
dc.subject.other | Anemia | en_US |
dc.subject.other | Liver, MR Studies | en_US |
dc.title | MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, Duke University Medical Center, 27710, Durham, NC, USA; Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, TC2910, 48109-0326, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8199554 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48141/1/261_2004_Article_BF00203497.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00203497 | en_US |
dc.identifier.source | Abdominal Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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