Show simple item record

Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia

dc.contributor.authorKocheril, Sosa V.en_US
dc.contributor.authorAppleton, Brent E.en_US
dc.contributor.authorSomers, Emily C.en_US
dc.contributor.authorKazerooni, Ella A.en_US
dc.contributor.authorFlaherty, Kevin R.en_US
dc.contributor.authorMartinez, Fernando J.en_US
dc.contributor.authorGross, B. H.en_US
dc.contributor.authorCrofford, Leslie J.en_US
dc.date.accessioned2006-09-20T15:01:13Z
dc.date.available2006-09-20T15:01:13Z
dc.date.issued2005-08-15en_US
dc.identifier.citationKocheril, S. V.; Appleton, B. E.; Somers, E. C.; Kazerooni, E. A.; Flaherty, K. R.; Martinez, F. J.; Gross, B. H.; Crofford, L. J. (2005)."Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia." Arthritis & Rheumatism 53(4): 549-557. <http://hdl.handle.net/2027.42/48677>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48677
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16082627&dopt=citationen_US
dc.description.abstractObjective To compare disease progression and mortality between idiopathic interstitial pneumonia (IIP) and interstitial lung disease (ILD) due to connective tissue diseases (CTD) including scleroderma, rheumatoid arthritis, systemic lupus, polymyositis, dermatomyositis, SjÖgren's syndrome, and mixed CTD. Methods A case-control study of patients with CTD-ILD (n = 46) and IIP controls (n = 51), seen at the University of Michigan between July 1,1998 and June 30,1999 and followed until March 30, 2002, was conducted. Survival analysis and Cox regression were performed to estimate survival, accounting for demographic and clinical parameters, including pulmonary function tests and high resolution computed tomography (HRCT) diagnosis and scoring. Results Median followup time was 4.4 person-years. Five-year survival in the IIP group was 51.9% (95% confidence interval [95% CI] 30.8–69.4) versus 43.4% (95% CI 21.1–63.9) in the CTD-ILD group. There were no significant differences among HRCT diagnostic categories between IIP and CTD-ILD. A fibrotic score ≥2 was associated with decreased survival among the entire group. Age at diagnosis and most recent forced vital capacity were significant predictors of mortality when adjusted for IIP versus CTD-ILD diagnosis, sex, and interstitial score. Conclusion Contrary to expectation, CTD-ILD compared with IIP appears to be associated with a worse prognosis when adjusted for age. A higher fibrotic score is suggestive of decreased survival.en_US
dc.format.extent171462 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.titleComparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumoniaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor ; Department of Internal Medicine, Division of Rheumatology, University of Michigan, 3918 Taubman Center Box: 358, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.identifier.pmid16082627en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48677/1/21322_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/art.21322en_US
dc.identifier.sourceArthritis & Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Accessibility: If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.