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Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT-C cohort Potential conflict of interest: Nothing to report.

dc.contributor.authorLok, Anna Suk-Fongen_US
dc.contributor.authorGhany, Marc G.en_US
dc.contributor.authorGoodman, Zachary D.en_US
dc.contributor.authorWright, Elizabeth C.en_US
dc.contributor.authorEverson, Gregory T.en_US
dc.contributor.authorSterling, Richard K.en_US
dc.contributor.authorEverhart, James E.en_US
dc.contributor.authorLindsay, Karen L.en_US
dc.contributor.authorBonkovsky, Herbert L.en_US
dc.contributor.authorDi Bisceglie, Adrian M.en_US
dc.contributor.authorLee, William M.en_US
dc.contributor.authorMorgan, Timothy R.en_US
dc.contributor.authorDienstag, Jules L.en_US
dc.contributor.authorMorishima, Chihiroen_US
dc.date.accessioned2006-09-20T15:01:41Z
dc.date.available2006-09-20T15:01:41Z
dc.date.issued2005-08en_US
dc.identifier.citationLok, Anna S. F.; Ghany, Marc G.; Goodman, Zachary D.; Wright, Elizabeth C.; Everson, Gregory T.; Sterling, Richard K.; Everhart, James E.; Lindsay, Karen L.; Bonkovsky, Herbert L.; Di Bisceglie, Adrian M.; Lee, William M.; Morgan, Timothy R.; Dienstag, Jules L.; Morishima, Chihiro (2005)."Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT-C cohort Potential conflict of interest: Nothing to report. ." Hepatology 42(2): 282-292. <http://hdl.handle.net/2027.42/48683>en_US
dc.identifier.issn0270-9139en_US
dc.identifier.issn1527-3350en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48683
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15986415&dopt=citationen_US
dc.description.abstractKnowledge of the presence of cirrhosis is important for the management of patients with chronic hepatitis C (CHC). Most models for predicting cirrhosis were derived from small numbers of patients and included subjective variables or laboratory tests that are not readily available. The aim of this study was to develop a predictive model of cirrhosis in patients with CHC based on standard laboratory tests. Data from 1,141 CHC patients including 429 with cirrhosis were analyzed. All biopsies were read by a panel of pathologists (blinded to clinical features), and fibrosis stage was determined by consensus. The cohort was divided into a training set (n = 783) and a validation set (n = 358). Variables that were significantly different between patients with and without cirrhosis in univariate analysis were entered into logistic regression models, and the performance of each model was compared. The area under the receiver-operating characteristic curve of the final model comprising platelet count, AST/ALT ratio, and INR in the training and validation sets was 0.78 and 0.81, respectively. A cutoff of less than 0.2 to exclude cirrhosis would misclassify only 7.8% of patients with cirrhosis, while a cutoff of greater than 0.5 to confirm cirrhosis would misclassify 14.8% of patients without cirrhosis. The model performed equally well in fragmented and nonfragmented biopsies and in biopsies of varying lengths. Use of this model might obviate the requirement for a liver biopsy in 50% of patients with CHC. In conclusion , a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC. (H EPATOLOGY 2005.)en_US
dc.format.extent155625 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherHepatologyen_US
dc.titlePredicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT-C cohort Potential conflict of interest: Nothing to report.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI ; fax: 734-936-7392 ; Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48109-0362en_US
dc.contributor.affiliationotherLiver Diseases Section, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MDen_US
dc.contributor.affiliationotherDivision of Hepatic Pathology and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Washington, DCen_US
dc.contributor.affiliationotherNew England Research Institutes, Watertown, MAen_US
dc.contributor.affiliationotherSection of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, COen_US
dc.contributor.affiliationotherDivision of Gastroenterology, Hepatology, and Nutrition, Hepatology Section, Virginia Commonwealth University Health System, Richmond, VAen_US
dc.contributor.affiliationotherDivision of Digestive Diseases and Nutrition, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MDen_US
dc.contributor.affiliationotherDivision of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, CAen_US
dc.contributor.affiliationotherLiver-Biliary-Pancreatic Center and the General Clinical Research Center, University of Connecticut Health Center, Farmington, CTen_US
dc.contributor.affiliationotherDivision of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, MOen_US
dc.contributor.affiliationotherDivision of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TXen_US
dc.contributor.affiliationotherDivision of Gastroenterology, University of California–Irvine, Irvine, CAen_US
dc.contributor.affiliationotherGastrointestinal Unit (Medical Services), Massachusetts General Hospital, Boston, MA ; Department of Medicine, Harvard Medical School, Boston, MAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, University of Washington, Seattle, WA ; Department of Laboratory Medicine, University of Washington, Seattle, WAen_US
dc.identifier.pmid15986415en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48683/1/20772_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/hep.20772en_US
dc.identifier.sourceHepatologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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