Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
dc.contributor.author | Gupta, Daya S. | en_US |
dc.contributor.author | McCullumsmith, Robert E. | en_US |
dc.contributor.author | Beneyto, Monica | en_US |
dc.contributor.author | Haroutunian, Vahram | en_US |
dc.contributor.author | Davis, Kenneth L. | en_US |
dc.contributor.author | Meador-Woodruff, James H. | en_US |
dc.date.accessioned | 2006-09-20T15:02:21Z | |
dc.date.available | 2006-09-20T15:02:21Z | |
dc.date.issued | 2005-09-01 | en_US |
dc.identifier.citation | Gupta, Daya S.; McCullumsmith, Robert E.; Beneyto, Monica; Haroutunian, Vahram; Davis, Kenneth L.; Meador-Woodruff, James H. (2005)."Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia." Synapse 57(3): 123-131. <http://hdl.handle.net/2027.42/48692> | en_US |
dc.identifier.issn | 0887-4476 | en_US |
dc.identifier.issn | 1098-2396 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48692 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15945063&dopt=citation | en_US |
dc.description.abstract | We investigated the expression of metabotropic glutamate receptors (mGluR) in the prefrontal cortex (PFC) and striatum in schizophrenia. mGluRs modulate the release and reuptake of synaptic glutamate and mediate some molecular correlates of neuroplasticity, including long-term potentiation. The mGluRs are expressed widely in the PFC and striatum, regions often implicated in the pathophysiology of schizophrenia. Thus, we hypothesized that abnormal expression of mGluRs might contribute to glutamatergic dysfunction observed in the PFC and striatum in schizophrenia. Accordingly, we measured the expression of metabotropic glutamate receptors (mGluRs) in Brodmann areas 9, 11, 32, and 46 in the prefrontal cortex (PFC) and the caudate, putamen, and nucleus accumbens in schizophrenia (16 cases, 9 controls) by Western blot analysis. We found an increase in the expression of mGluR1a and mGluR2/3 immunoreactivity in the PFC in schizophrenia, while no changes in the expression of mGluR4a or mGluR5 were detected in this region. In the striatum we found no changes in the expression of any of the mGluRs studied. These results suggest that alterations of mGluR1a and mGluR2/3 expression in the PFC may contribute to the pathophysiology of schizophrenia, and support targeting these receptors for the generation of novel treatment modalities for this disabling illness. Synapse 57:123–131, 2005. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 247298 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan ; Mental Health Research Institute and Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720 | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Mount Sinai School of Medicine, New York, New York | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Mount Sinai School of Medicine, New York, New York | en_US |
dc.identifier.pmid | 15945063 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48692/1/20164_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/syn.20164 | en_US |
dc.identifier.source | Synapse | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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