Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia

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dc.contributor.author Gupta, Daya S. en_US
dc.contributor.author McCullumsmith, Robert E. en_US
dc.contributor.author Beneyto, Monica en_US
dc.contributor.author Haroutunian, Vahram en_US
dc.contributor.author Davis, Kenneth L. en_US
dc.contributor.author Meador-Woodruff, James H. en_US
dc.date.accessioned 2006-09-20T15:02:21Z
dc.date.available 2006-09-20T15:02:21Z
dc.date.issued 2005-09-01 en_US
dc.identifier.citation Gupta, Daya S.; McCullumsmith, Robert E.; Beneyto, Monica; Haroutunian, Vahram; Davis, Kenneth L.; Meador-Woodruff, James H. (2005)."Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia." Synapse 57(3): 123-131. <http://hdl.handle.net/2027.42/48692> en_US
dc.identifier.issn 0887-4476 en_US
dc.identifier.issn 1098-2396 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/48692
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15945063&dopt=citation en_US
dc.description.abstract We investigated the expression of metabotropic glutamate receptors (mGluR) in the prefrontal cortex (PFC) and striatum in schizophrenia. mGluRs modulate the release and reuptake of synaptic glutamate and mediate some molecular correlates of neuroplasticity, including long-term potentiation. The mGluRs are expressed widely in the PFC and striatum, regions often implicated in the pathophysiology of schizophrenia. Thus, we hypothesized that abnormal expression of mGluRs might contribute to glutamatergic dysfunction observed in the PFC and striatum in schizophrenia. Accordingly, we measured the expression of metabotropic glutamate receptors (mGluRs) in Brodmann areas 9, 11, 32, and 46 in the prefrontal cortex (PFC) and the caudate, putamen, and nucleus accumbens in schizophrenia (16 cases, 9 controls) by Western blot analysis. We found an increase in the expression of mGluR1a and mGluR2/3 immunoreactivity in the PFC in schizophrenia, while no changes in the expression of mGluR4a or mGluR5 were detected in this region. In the striatum we found no changes in the expression of any of the mGluRs studied. These results suggest that alterations of mGluR1a and mGluR2/3 expression in the PFC may contribute to the pathophysiology of schizophrenia, and support targeting these receptors for the generation of novel treatment modalities for this disabling illness. Synapse 57:123–131, 2005. © 2005 Wiley-Liss, Inc. en_US
dc.format.extent 247298 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan en_US
dc.contributor.affiliationum Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan ; Mental Health Research Institute and Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720 en_US
dc.contributor.affiliationum Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan en_US
dc.contributor.affiliationum Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan en_US
dc.contributor.affiliationother Department of Psychiatry, Mount Sinai School of Medicine, New York, New York en_US
dc.contributor.affiliationother Department of Psychiatry, Mount Sinai School of Medicine, New York, New York en_US
dc.identifier.pmid 15945063 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/48692/1/20164_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/syn.20164 en_US
dc.identifier.source Synapse en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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