Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules
dc.contributor.author | Swarte, Vivette V. R. | en_US |
dc.contributor.author | Joziasse, David H. | en_US |
dc.contributor.author | Van den Eijnden, Dirk H. | en_US |
dc.contributor.author | Petryniak, Bronislawa | en_US |
dc.contributor.author | Lowe, John B. | en_US |
dc.contributor.author | Kraal, Georg | en_US |
dc.contributor.author | Mebius, Reina E. | en_US |
dc.date.accessioned | 2006-09-20T15:03:25Z | |
dc.date.available | 2006-09-20T15:03:25Z | |
dc.date.issued | 1998-10 | en_US |
dc.identifier.citation | Swarte, Vivette V. R.; Joziasse, David H.; Van den Eijnden, Dirk H.; Petryniak, Bronislawa; Lowe, John B.; Kraal, Georg; Mebius, Reina E. (1998)."Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules." European Journal of Immunology 28(10): 3040-3047. <http://hdl.handle.net/2027.42/48706> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48706 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9808172&dopt=citation | en_US |
dc.description.abstract | Binding of L-selectin to the highly glycosylated peripheral lymph node addressins (PNAd) plays a central role in the normal recirculation of lymphocytes between the bloodstream and the lymph node. This interaction requires correct fucosylation of the PNAd, mediated by the recently identified fucosyltransferase-VII (Fuc-TVII). Here we show that during ontogeny Fuc-TVII is absent at the day of birth, barely detectable on day 1, and clearly present from day 2 onwards. PNAd expression as detected by the MECA-79 antibody precedes the expression of Fuc-TVII. Furthermore, we demonstrate that in adult mice antigenic stimulation of peripheral lymph nodes leads to a temporary disappearance of Fuc-TVII at days 2 and 3 after stimulation, followed by a complete reappearance by day 4, while expression of MECA-79 is never completely absent during this period. Finally, occlusion of afferent lymphatics to peripheral lymph nodes resulted in a decreased expression of Fuc-TVII in the high endothelial venules by day 5, and complete disappearance within 8 days. We conclude that the activity of Fuc-TVII in cells of high endothelial venules is directly affected by afferent lymph and activation processes that occur in the lymph node after antigenic stimulation. The expression of Fuc-TVII is therefore yet another level at which the function of high endothelial venules, and thus lymphocyte trafficking, can be regulated. | en_US |
dc.format.extent | 160346 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | WILEY-VCH Verlag GmbH | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Howard Hughes Medical Research Institute, University of Michigan, Ann Arbor, USA | en_US |
dc.contributor.affiliationum | Department of Pathology and Howard Hughes Medical Research Institute, University of Michigan, Ann Arbor, USA | en_US |
dc.contributor.affiliationother | Department of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands | en_US |
dc.identifier.pmid | 9808172 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48706/1/3040_ftp.pdf | en_US |
dc.identifier.doi | 10.1002/(ISSN)1521-4141 | |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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