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dc.contributor.authorSwarte, Vivette V. R.en_US
dc.contributor.authorJoziasse, David H.en_US
dc.contributor.authorVan den Eijnden, Dirk H.en_US
dc.contributor.authorPetryniak, Bronislawaen_US
dc.contributor.authorLowe, John B.en_US
dc.contributor.authorKraal, Georgen_US
dc.contributor.authorMebius, Reina E.en_US
dc.date.accessioned2006-09-20T15:03:25Z
dc.date.available2006-09-20T15:03:25Z
dc.date.issued1998-10en_US
dc.identifier.citationSwarte, Vivette V. R.; Joziasse, David H.; Van den Eijnden, Dirk H.; Petryniak, Bronislawa; Lowe, John B.; Kraal, Georg; Mebius, Reina E. (1998)."Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules." European Journal of Immunology 28(10): 3040-3047. <http://hdl.handle.net/2027.42/48706>en_US
dc.identifier.issn0014-2980en_US
dc.identifier.issn1521-4141en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48706
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9808172&dopt=citationen_US
dc.description.abstractBinding of L-selectin to the highly glycosylated peripheral lymph node addressins (PNAd) plays a central role in the normal recirculation of lymphocytes between the bloodstream and the lymph node. This interaction requires correct fucosylation of the PNAd, mediated by the recently identified fucosyltransferase-VII (Fuc-TVII). Here we show that during ontogeny Fuc-TVII is absent at the day of birth, barely detectable on day 1, and clearly present from day 2 onwards. PNAd expression as detected by the MECA-79 antibody precedes the expression of Fuc-TVII. Furthermore, we demonstrate that in adult mice antigenic stimulation of peripheral lymph nodes leads to a temporary disappearance of Fuc-TVII at days 2 and 3 after stimulation, followed by a complete reappearance by day 4, while expression of MECA-79 is never completely absent during this period. Finally, occlusion of afferent lymphatics to peripheral lymph nodes resulted in a decreased expression of Fuc-TVII in the high endothelial venules by day 5, and complete disappearance within 8 days. We conclude that the activity of Fuc-TVII in cells of high endothelial venules is directly affected by afferent lymph and activation processes that occur in the lymph node after antigenic stimulation. The expression of Fuc-TVII is therefore yet another level at which the function of high endothelial venules, and thus lymphocyte trafficking, can be regulated.en_US
dc.format.extent160346 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWILEY-VCH Verlag GmbHen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherMicrobiology and Immunologyen_US
dc.titleRegulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venulesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology and Howard Hughes Medical Research Institute, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationumDepartment of Pathology and Howard Hughes Medical Research Institute, University of Michigan, Ann Arbor, USAen_US
dc.contributor.affiliationotherDepartment of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlandsen_US
dc.contributor.affiliationotherDepartment of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlandsen_US
dc.contributor.affiliationotherDepartment of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlandsen_US
dc.contributor.affiliationotherDepartment of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlandsen_US
dc.contributor.affiliationotherDepartment of Cell Biology and Immunology Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlandsen_US
dc.identifier.pmid9808172en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48706/1/3040_ftp.pdfen_US
dc.identifier.doi10.1002/(ISSN)1521-4141
dc.identifier.sourceEuropean Journal of Immunologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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