Show simple item record

A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions

dc.contributor.authorLoberg, Robert D.en_US
dc.contributor.authorGayed, Bishoy A.en_US
dc.contributor.authorOlson, Karin B.en_US
dc.contributor.authorPienta, Kenneth J.en_US
dc.date.accessioned2006-12-07T16:52:07Z
dc.date.available2006-12-07T16:52:07Z
dc.date.issued2005-10-15en_US
dc.identifier.citationLoberg, Robert D.; Gayed, Bishoy A.; Olson, Karin B.; Pienta, Kenneth J. (2005)."A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions." Journal of Cellular Biochemistry 96(3): 439-446. <http://hdl.handle.net/2027.42/48763>en_US
dc.identifier.issn0730-2312en_US
dc.identifier.issn1097-4644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48763
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15988761&dopt=citationen_US
dc.description.abstractThe pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous “hurdle” to overcome in designing novel cancer therapeutics. New targets of therapy are essential if we are to effectively overcome the evasiveness of cancer. The interaction between the tumor cell and the surrounding microenvironment creates a vicious cycle that perpetuates disease survival and progression. The future of cancer therapy resides in the ability to focus on the recruited and exploited relationships of the cancer cell with the host environment. These therapies target cancer cell growth early and interrupt the vicious cycle that is created by the tumor cells interacting with bone components by inhibiting osteoclasts, osteoblasts, stromal cells, and endothelial cells. They alter the bone microenvironment, creating a hostile “soil” that prevents the “seed” from developing into bone metastases and represent a potential new platform for the development of prostate cancer therapeutics. © 2005 Wiley-Liss, Inc.en_US
dc.format.extent116445 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleA paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactionsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Urology and Internal Medicine, University of Michigan Urology Center, The University of Michigan, Ann Arbor, Michigan ; University of Michigan Urology Center, 7431 CCGC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0946.en_US
dc.contributor.affiliationumDepartments of Urology and Internal Medicine, University of Michigan Urology Center, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Urology and Internal Medicine, University of Michigan Urology Center, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Urology and Internal Medicine, University of Michigan Urology Center, The University of Michigan, Ann Arbor, Michiganen_US
dc.identifier.pmid15988761en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48763/1/20522_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jcb.20522en_US
dc.identifier.sourceJournal of Cellular Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record