Advances in on-chip photodetection for applications in miniaturized genetic analysis systems
dc.contributor.author | Namasivayam, Vijay | en_US |
dc.contributor.author | Lin, Rongsheng | en_US |
dc.contributor.author | Johnson, Brian | en_US |
dc.contributor.author | Brahmasandra, Sundaresh | en_US |
dc.contributor.author | Razzacki, Zafar | en_US |
dc.contributor.author | Burke, David T. | en_US |
dc.contributor.author | Burns, Mark A. | en_US |
dc.date.accessioned | 2006-12-19T19:09:40Z | |
dc.date.available | 2006-12-19T19:09:40Z | |
dc.date.issued | 2004-01-01 | en_US |
dc.identifier.citation | Namasivayam, Vijay; Lin, Rongsheng; Johnson, Brian; Brahmasandra, Sundaresh; Razzacki, Zafar; Burke, David T; Burns, Mark A (2004). "Advances in on-chip photodetection for applications in miniaturized genetic analysis systems." Journal of Micromechanics and Microengineering. 14(1): 81-90. <http://hdl.handle.net/2027.42/49042> | en_US |
dc.identifier.issn | 0960-1317 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49042 | |
dc.description.abstract | Microfabrication techniques have become increasingly popular in the development of next generation DNA analysis devices. Improved on-chip fluorescence detection systems may have applications in developing portable hand-held instruments for point-of-care diagnostics. Miniaturization of fluorescence detection involves construction of ultra-sensitive photodetectors that can be integrated onto a fluidic platform combined with the appropriate optical emission filters. We have previously demonstrated integration PIN photodiodes onto a microfabricated electrophoresis channel for separation and detection of DNA fragments. In this work, we present an improved detector structure that uses a PINN+ photodiode with an on-chip interference filter and a robust liquid barrier layer. This new design yields high sensitivity (detection limit of 0.9 ng µl−1 of DNA), low-noise (S/N ∼ 100/1) and enhanced quantum efficiencies (>80%) over the entire visible spectrum. Applications of these photodiodes in various areas of DNA analysis such as microreactions (PCR), separations (electrophoresis) and microfluidics (drop sensing) are presented. | en_US |
dc.format.extent | 3118 bytes | |
dc.format.extent | 315070 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.publisher | IOP Publishing Ltd | en_US |
dc.title | Advances in on-chip photodetection for applications in miniaturized genetic analysis systems | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA; Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109-2136, USA; | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA; Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109-2136, USA; | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, The University of Michigan, Ann Arbor, MI 48109-2136, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49042/2/jm4111.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1088/0960-1317/14/1/311 | en_US |
dc.identifier.source | Journal of Micromechanics and Microengineering. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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