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Advances in on-chip photodetection for applications in miniaturized genetic analysis systems

dc.contributor.authorNamasivayam, Vijayen_US
dc.contributor.authorLin, Rongshengen_US
dc.contributor.authorJohnson, Brianen_US
dc.contributor.authorBrahmasandra, Sundareshen_US
dc.contributor.authorRazzacki, Zafaren_US
dc.contributor.authorBurke, David T.en_US
dc.contributor.authorBurns, Mark A.en_US
dc.date.accessioned2006-12-19T19:09:40Z
dc.date.available2006-12-19T19:09:40Z
dc.date.issued2004-01-01en_US
dc.identifier.citationNamasivayam, Vijay; Lin, Rongsheng; Johnson, Brian; Brahmasandra, Sundaresh; Razzacki, Zafar; Burke, David T; Burns, Mark A (2004). "Advances in on-chip photodetection for applications in miniaturized genetic analysis systems." Journal of Micromechanics and Microengineering. 14(1): 81-90. <http://hdl.handle.net/2027.42/49042>en_US
dc.identifier.issn0960-1317en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49042
dc.description.abstractMicrofabrication techniques have become increasingly popular in the development of next generation DNA analysis devices. Improved on-chip fluorescence detection systems may have applications in developing portable hand-held instruments for point-of-care diagnostics. Miniaturization of fluorescence detection involves construction of ultra-sensitive photodetectors that can be integrated onto a fluidic platform combined with the appropriate optical emission filters. We have previously demonstrated integration PIN photodiodes onto a microfabricated electrophoresis channel for separation and detection of DNA fragments. In this work, we present an improved detector structure that uses a PINN+ photodiode with an on-chip interference filter and a robust liquid barrier layer. This new design yields high sensitivity (detection limit of 0.9 ng µl−1 of DNA), low-noise (S/N ∼ 100/1) and enhanced quantum efficiencies (>80%) over the entire visible spectrum. Applications of these photodiodes in various areas of DNA analysis such as microreactions (PCR), separations (electrophoresis) and microfluidics (drop sensing) are presented.en_US
dc.format.extent3118 bytes
dc.format.extent315070 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherIOP Publishing Ltden_US
dc.titleAdvances in on-chip photodetection for applications in miniaturized genetic analysis systemsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA; Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109-2136, USA;en_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA; Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109-2136, USA;en_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USAen_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USAen_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, The University of Michigan, Ann Arbor, MI 48109-2136, USAen_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49042/2/jm4111.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1088/0960-1317/14/1/311en_US
dc.identifier.sourceJournal of Micromechanics and Microengineering.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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