A versatile microreactor platform featuring a chemical-resistant microvalve array for addressable multiplex syntheses and assays

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dc.contributor.author Hua, Zhishan en_US
dc.contributor.author Xia, Yongmei en_US
dc.contributor.author Srivannavit, Onnop en_US
dc.contributor.author Rouillard, Jean-Marie en_US
dc.contributor.author Zhou, Xiaochuan en_US
dc.contributor.author Gao, Xiaolian en_US
dc.contributor.author Gulari, Erdogan en_US
dc.date.accessioned 2006-12-19T19:10:25Z
dc.date.available 2006-12-19T19:10:25Z
dc.date.issued 2006-08-01 en_US
dc.identifier.citation Hua, Zhishan; Xia, Yongmei; Srivannavit, Onnop; Rouillard, Jean-Marie; Zhou, Xiaochuan; Gao, Xiaolian; Gulari, Erdogan (2006). "A versatile microreactor platform featuring a chemical-resistant microvalve array for addressable multiplex syntheses and assays." Journal of Micromechanics and Microengineering. 16(8): 1433-1443. <http://hdl.handle.net/2027.42/49051> en_US
dc.identifier.issn 0960-1317 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/49051
dc.description.abstract A versatile microreactor platform featuring a novel chemical-resistant microvalve array has been developed using combined silicon/polymer micromachining and a special polymer membrane transfer process. The basic valve unit in the array has a typical ‘transistor’ structure and a PDMS/parylene double-layer valve membrane. A robust multiplexing algorithm is also proposed for individual addressing of a large array using a minimal number of signal inputs. The in-channel microvalve is leakproof upon pneumatic actuation. In open status it introduces small impedance to the fluidic flow, and allows a significantly larger dynamic range of flow rates (∼ml min−1) compared with most of the microvalves reported. Equivalent electronic circuits were established by modeling the microvalves as PMOS transistors and the fluidic channels as simple resistors to provide theoretical prediction of the device fluidic behavior. The presented microvalve/reactor array showed excellent chemical compatibility in the tests with several typical aggressive chemicals including those seriously degrading PDMS-based microfluidic devices. Combined with the multiplexing strategy, this versatile array platform can find a variety of lab-on-a-chip applications such as addressable multiplex biochemical synthesis/assays, and is particularly suitable for those requiring tough chemicals, large flow rates and/or high-throughput parallel processing. As an example, the device performance was examined through the addressed synthesis of 30-mer DNA oligonucleotides followed by sequence validation using on-chip hybridization. The results showed leakage-free valve array addressing and proper synthesis in target reactors, as well as uniform flow distribution and excellent regional reaction selectivity. en_US
dc.format.extent 3118 bytes
dc.format.extent 627022 bytes
dc.format.mimetype text/plain
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher IOP Publishing Ltd en_US
dc.title A versatile microreactor platform featuring a chemical-resistant microvalve array for addressable multiplex syntheses and assays en_US
dc.subject.hlbsecondlevel Physics en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA en_US
dc.contributor.affiliationum Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA en_US
dc.contributor.affiliationum Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA en_US
dc.contributor.affiliationum Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA en_US
dc.contributor.affiliationum Department of Chemical Engineering, The University of Michigan, Ann Arbor, MI 48109-2136, USA en_US
dc.contributor.affiliationother Atactic Technologies, Houston, TX 77054, USA en_US
dc.contributor.affiliationother Department of Chemistry, University of Houston, Houston, TX 77004-5003, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/49051/2/jmm6_8_001.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1088/0960-1317/16/8/001 en_US
dc.identifier.source Journal of Micromechanics and Microengineering. en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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