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dc.contributor.authorBuras, Eric D.en_US
dc.contributor.authorHolt, Avril Geneneen_US
dc.contributor.authorGriffith, Ronald D.en_US
dc.contributor.authorAsako, Mikiyaen_US
dc.contributor.authorAltschuler, Richard A.en_US
dc.date.accessioned2007-01-17T15:52:14Z
dc.date.available2007-01-17T15:52:14Z
dc.date.issued2006-01-01en_US
dc.identifier.citationBuras, Eric D.; Holt, Avril Genene; Griffith, Ronald D.; Asako, Mikiya; Altschuler, Richard A. (2006)."Changes in glycine immunoreactivity in the rat superior olivary complex following deafness." The Journal of Comparative Neurology 494(1): 179-189. <http://hdl.handle.net/2027.42/49273>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49273
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16304686&dopt=citationen_US
dc.description.abstractThe balance between inhibitory and excitatory amino acid neurotransmitters contributes to the control of normal functioning of the auditory brainstem. Changes in the level of neuronal activity within the auditory brainstem pathways influence the balance between inhibition and excitation. Activity-dependent plasticity in the auditory pathways can be studied by creating a large decrease in activity through peripheral deafening. Deafness-related decreases in GABA have previously been shown in the inferior colliculus. However, glycine is a more prevalent inhibitory transmitter in the mature superior olivary complex (SOC). The present study therefore examined if there were deafness-related changes in glycine in the SOC using postembedding immunocytochemistry. Animals were bilaterally deafened by an intrascalar injection of neomycin. Five nuclei in the SOC, the lateral superior olive (LSO), superior paraolivary nucleus (SPoN), and the medial, lateral, and ventral nuclei of the trapezoid body (MNTB, LNTB, and VNTB) were examined 14 days following the deafening and compared to normal hearing age-matched controls. The LSO and SPoN were divided into high and low frequency regions. The number of glycine immunoreactive puncta on the somata of principal cells showed significant decreases in all regions assessed, with changes ranging from 50% in the VNTB to 23% in the LSO. J. Comp. Neurol. 494:179–189, 2006. © 2005 Wiley-Liss, Inc.en_US
dc.format.extent1220167 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleChanges in glycine immunoreactivity in the rat superior olivary complex following deafnessen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; The first two authors contributed equally to the study.en_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; KHRI, Department of Otolaryngology, The University of Michigan, 1301 East Ann St., Ann Arbor, MI 48109-0506en_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Otolaryngology, Kansai Medical University, Osaka 570-8506, Japanen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid16304686en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49273/1/20795_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.20795en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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