Changes in glycine immunoreactivity in the rat superior olivary complex following deafness
dc.contributor.author | Buras, Eric D. | en_US |
dc.contributor.author | Holt, Avril Genene | en_US |
dc.contributor.author | Griffith, Ronald D. | en_US |
dc.contributor.author | Asako, Mikiya | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2007-01-17T15:52:14Z | |
dc.date.available | 2007-01-17T15:52:14Z | |
dc.date.issued | 2006-01-01 | en_US |
dc.identifier.citation | Buras, Eric D.; Holt, Avril Genene; Griffith, Ronald D.; Asako, Mikiya; Altschuler, Richard A. (2006)."Changes in glycine immunoreactivity in the rat superior olivary complex following deafness." The Journal of Comparative Neurology 494(1): 179-189. <http://hdl.handle.net/2027.42/49273> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49273 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16304686&dopt=citation | en_US |
dc.description.abstract | The balance between inhibitory and excitatory amino acid neurotransmitters contributes to the control of normal functioning of the auditory brainstem. Changes in the level of neuronal activity within the auditory brainstem pathways influence the balance between inhibition and excitation. Activity-dependent plasticity in the auditory pathways can be studied by creating a large decrease in activity through peripheral deafening. Deafness-related decreases in GABA have previously been shown in the inferior colliculus. However, glycine is a more prevalent inhibitory transmitter in the mature superior olivary complex (SOC). The present study therefore examined if there were deafness-related changes in glycine in the SOC using postembedding immunocytochemistry. Animals were bilaterally deafened by an intrascalar injection of neomycin. Five nuclei in the SOC, the lateral superior olive (LSO), superior paraolivary nucleus (SPoN), and the medial, lateral, and ventral nuclei of the trapezoid body (MNTB, LNTB, and VNTB) were examined 14 days following the deafening and compared to normal hearing age-matched controls. The LSO and SPoN were divided into high and low frequency regions. The number of glycine immunoreactive puncta on the somata of principal cells showed significant decreases in all regions assessed, with changes ranging from 50% in the VNTB to 23% in the LSO. J. Comp. Neurol. 494:179–189, 2006. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 1220167 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Changes in glycine immunoreactivity in the rat superior olivary complex following deafness | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; The first two authors contributed equally to the study. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; KHRI, Department of Otolaryngology, The University of Michigan, 1301 East Ann St., Ann Arbor, MI 48109-0506 | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Otolaryngology, Kansai Medical University, Osaka 570-8506, Japan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 16304686 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49273/1/20795_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cne.20795 | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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