Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy

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dc.contributor.author Parent, Jack M. en_US
dc.contributor.author Elliott, Robert C. en_US
dc.contributor.author Pleasure, Samuel J. en_US
dc.contributor.author Barbaro, Nicholas M. en_US
dc.contributor.author Lowenstein, Daniel H. en_US
dc.date.accessioned 2007-01-17T15:52:56Z
dc.date.available 2007-01-17T15:52:56Z
dc.date.issued 2006-01 en_US
dc.identifier.citation Parent, Jack M.; Elliott, Robert C.; Pleasure, Samuel J.; Barbaro, Nicholas M.; Lowenstein, Daniel H. (2006)."Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy." Annals of Neurology 59(1): 81-91. <http://hdl.handle.net/2027.42/49280> en_US
dc.identifier.issn 0364-5134 en_US
dc.identifier.issn 1531-8249 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/49280
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16261566&dopt=citation en_US
dc.description.abstract Neurogenesis in the hippocampal dentate gyrus persists throughout life and is increased by seizures. The dentate granule cell (DGC) layer is often abnormal in human and experimental temporal lobe epilepsy, with dispersion of the layer and the appearance of ectopic granule neurons in the hilus. We tested the hypothesis that these abnormalities result from aberrant DGC neurogenesis after seizure-induced injury. Bromodeoxyuridine labeling, in situ hybridization, and immunohistochemistry were used to identify proliferating progenitors and mature DGCs in the adult rat pilocarpine temporal lobe epilepsy model. We also examined dentate gyri from epileptic human hippocampal surgical specimens. Prox-1 immunohistochemistry and pulse-chase bromodeoxyuridine labeling showed that progenitors migrate aberrantly to the hilus and molecular layer after prolonged seizures and differentiate into ectopic DGCs in rat. Neuroblast marker expression indicated the delayed appearance of chainlike progenitor cell formations extending into the hilus and molecular layer, suggesting that seizures alter migratory behavior of DGC precursors. Ectopic putative DGCs also were found in the hilus and molecular layer of epileptic human dentate gyrus. These findings indicate that seizure-induced abnormalities of neuroblast migration lead to abnormal integration of newborn DGCs in the epileptic adult hippocampus, and implicate aberrant neurogenesis in the development or progression of recurrent seizures. Ann Neurol 2005 en_US
dc.format.extent 761185 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology, and Psychiatry en_US
dc.title Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Psychiatry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI ; Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0585 en_US
dc.contributor.affiliationother National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD en_US
dc.contributor.affiliationother Department of Neurology, University of California, San Francisco, San Francisco, CA en_US
dc.contributor.affiliationother Department of Neurosurgery, University of California, San Francisco, San Francisco, CA en_US
dc.contributor.affiliationother Department of Neurology, University of California, San Francisco, San Francisco, CA en_US
dc.identifier.pmid 16261566 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/49280/1/20699_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/ana.20699 en_US
dc.identifier.source Annals of Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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