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dc.contributor.authorFlanders, Scott A.en_US
dc.contributor.authorDudas, Vickyen_US
dc.contributor.authorKerr, Kathleenen_US
dc.contributor.authorMcCulloch, Charles E.en_US
dc.contributor.authorGonzales, Ralphen_US
dc.date.accessioned2007-01-17T15:53:59Z
dc.date.available2007-01-17T15:53:59Z
dc.date.issued2006-01en_US
dc.identifier.citationFlanders, Scott A.; Dudas, Vicky; Kerr, Kathleen; McCulloch, Charles E.; Gonzales, Ralph (2006)."Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia Presented, in part, at the 6th Annual Meeting of the Society of Hospital Medicine, San Diego, CA, April 1, 2003, and at the 26th Annual Meeting of the Society of General Internal Medicine, Vancouver, BC, Canada, May 3, 2003. ." Journal of Hospital Medicine 1(1): 7-12. <http://hdl.handle.net/2027.42/49291>en_US
dc.identifier.issn1553-5592en_US
dc.identifier.issn1553-5606en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49291
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17219465&dopt=citationen_US
dc.description.abstractBACKGROUND: Limited data exist on the effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia (CAP). METHODS: We performed a retrospective cohort study of all adults hospitalized for pneumonia between January 1999 and July 2001 at an academic medical center. Outcomes were compared for patients with CAP treated with ceftriaxone plus doxycycline versus other appropriate initial empiric antibiotic therapies. Outcomes were adjusted with the use of a propensity score to account for differences in patient characteristics and illness severity between groups. RESULTS: A total of 216 patients were treated with ceftriaxone plus doxycycline and 125 received other appropriate initial empiric antibiotic therapies. After adjustment, use of ceftriaxone plus doxycycline was associated with reduced inpatient mortality (OR = 0.26, 95% CI: 0.08–0.81) and 30-day mortality (OR = 0.37, 95% CI: 0.17–0.81), but not with length of stay or readmission rates. Analysis of a subset of the sample that excluded patients admitted from nursing homes, patients admitted to the ICU, and patients diagnosed with aspiration also showed reduced inpatient mortality with the use of ceftriaxone plus doxycycline. CONCLUSIONS: The use of ceftriaxone plus doxycycline as an initial empiric therapy for patients hospitalized with CAP appears safe and effective, and its potential superiority should be evaluated prospectively. Journal of Hospital Medicine 2006;1:7–12. © 2006 Society of Hospital Medicine.en_US
dc.format.extent80973 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherHospital Medicineen_US
dc.titleEffectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia Presented, in part, at the 6th Annual Meeting of the Society of Hospital Medicine, San Diego, CA, April 1, 2003, and at the 26th Annual Meeting of the Society of General Internal Medicine, Vancouver, BC, Canada, May 3, 2003.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicine, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 615-8401 ; University of Michigan, 3119F Taubman Center, Box 0376, 1500 E. Medical Center Drive, Ann Arbor, MI 48109en_US
dc.contributor.affiliationotherDepartment of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, Californiaen_US
dc.contributor.affiliationotherDepartment of Medicine, University of California, San Francisco, San Francisco, Californiaen_US
dc.contributor.affiliationotherDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Californiaen_US
dc.contributor.affiliationotherDepartment of Medicine, University of California, San Francisco, San Francisco, California ; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California ; Division of General Internal Medicine, University of California, San Francisco, San Francisco, Californiaen_US
dc.identifier.pmid17219465en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49291/1/8_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jhm.8en_US
dc.identifier.sourceJournal of Hospital Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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