Cortisol pulsatility and its role in stress regulation and health
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.contributor.author | Abelson, James L. | en_US |
dc.contributor.author | Lightman, Stafford L. | en_US |
dc.date.accessioned | 2007-03-16T18:28:09Z | |
dc.date.available | 2007-03-16T18:28:09Z | |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Frontiers in Neuroendocrinology 25:69-76, 2004 <http://hdl.handle.net/2027.42/49484> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49484 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15571755&dopt=citation | en_US |
dc.description | commentary | en_US |
dc.description.abstract | One of the classic characteristics of the human stress response is the wide inter-individual variation. Although there is much current interest in the genetic and environmental contributions to these differences, studies on human subject have been sparse and characterised by methodological problems. The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo–pituitary–adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes. In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease. | en_US |
dc.description.sponsorship | NIMH MH50030 NIMH MH52724 | en_US |
dc.format.extent | 1347 bytes | |
dc.format.extent | 766410 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | HPA Axis | en_US |
dc.subject | Hormone Pulsatility | en_US |
dc.title | Cortisol pulsatility and its role in stress regulation and health | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Psychiatry | en_US |
dc.contributor.affiliationum | Molecular and Behavioral Neurosciences Institute | en_US |
dc.contributor.affiliationother | Medicine, Bristol Royal Infirmary | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15571755 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49484/2/cortisolpulseLightman.pdf | en_US |
dc.identifier.source | Frontiers in Neuroendocrinology | en_US |
dc.owningcollname | Molecular and Behavioral Neurosciences Institute |
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