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dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorAbelson, James L.en_US
dc.contributor.authorLightman, Stafford L.en_US
dc.date.accessioned2007-03-16T18:28:09Z
dc.date.available2007-03-16T18:28:09Z
dc.date.issued2004en_US
dc.identifier.citationFrontiers in Neuroendocrinology 25:69-76, 2004 <http://hdl.handle.net/2027.42/49484>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49484
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15571755&dopt=citationen_US
dc.descriptioncommentaryen_US
dc.description.abstractOne of the classic characteristics of the human stress response is the wide inter-individual variation. Although there is much current interest in the genetic and environmental contributions to these differences, studies on human subject have been sparse and characterised by methodological problems. The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo–pituitary–adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes. In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease.en_US
dc.description.sponsorshipNIMH MH50030 NIMH MH52724en_US
dc.format.extent1347 bytes
dc.format.extent766410 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectHPA Axisen_US
dc.subjectHormone Pulsatilityen_US
dc.titleCortisol pulsatility and its role in stress regulation and healthen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular, and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPsychiatryen_US
dc.contributor.affiliationumMolecular and Behavioral Neurosciences Instituteen_US
dc.contributor.affiliationotherMedicine, Bristol Royal Infirmaryen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15571755en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49484/2/cortisolpulseLightman.pdfen_US
dc.identifier.sourceFrontiers in Neuroendocrinologyen_US
dc.owningcollnameMolecular and Behavioral Neurosciences Institute


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