The pattern of growth hormone secretion during the menstrual cycle in normal and depressed women
dc.contributor.author | Kasa-Vubu, Josephine Z. | en_US |
dc.contributor.author | Dimaraki, Eleni V. | en_US |
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.date.accessioned | 2007-03-16T18:28:21Z | |
dc.date.available | 2007-03-16T18:28:21Z | |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Clinical Endocrinology 62:656-60, 2005 <http://hdl.handle.net/2027.42/49486> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49486 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15943825&dopt=citation | en_US |
dc.description.abstract | Objective Major depression is associated to altered hypothalamic pituitary function. Stress is linked to elevated cortisol as well as menstrual cycle disturbance; however, there is no known relationship between depression and menstrual cycle disruption. The aim of this study was to investigate changes of growth hormone (GH) secretion during the menstrual cycle in normal and depressed women. Design Case-control study. Patients and methods Nineteen women affected with depression and 24 normal controls were included. The two groups had comparable body mass index (BMI), and age (29·4 ±9·8 vs. 28·6 ± 9·7 years). Nine depressed and 10 controls were studied in the follicular phase, while 10 depressed and 14 controls were studied in the luteal phase of the cycle. GH was sampled every 10 min for 24 h, and the data were analysed by the cluster pulse detection method. Results There was no difference in 24-h mean GH concentrations between depressed and control subjects (P =0·93), even after accounting for menstrual cycle phase (P = 0·38). GH pulse frequency was higher during the follicular phase of the cycle (P =0·032), and nocturnal GH was higher in the follicular phase of the cycle (P =0·05, and after adjusting for 24-h GH, P= 0·0138) regardless of whether thesubjects were depressed or healthy. Conclusions In studies of GH secretion in women with or without depression, it is necessary to control for the phase of menstrual cycle. | en_US |
dc.description.sponsorship | NIMH MH 50030 NICHD K12HD01438 | en_US |
dc.format.extent | 1347 bytes | |
dc.format.extent | 169426 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | Blackwell | en_US |
dc.subject | Stress | en_US |
dc.subject | Growth Hormone | en_US |
dc.title | The pattern of growth hormone secretion during the menstrual cycle in normal and depressed women | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Pediatrics | en_US |
dc.contributor.affiliationum | Internal Medicine | en_US |
dc.contributor.affiliationum | Psychiatry | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15943825 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49486/2/KasaVubuYoung.pdf | en_US |
dc.owningcollname | Molecular and Behavioral Neurosciences Institute |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.